Thermoelectric generators (TEGs) have shown great potentials to supply low-power sensor nodes in aerospace applications due to their relatively small size, adequate output power and reliability. TEGs convert waste heat available at aircraft locations into a usable potential difference. However, TEGs’ performance greatly depends on the use of passive cooling systems such as heatsinks to enhance their energy supply. This paper reports the first proof-of-concept use of vapour chambers coupled to traditional circular pin-fin heatsinks to enhance the output power of TEGs. Vapour chambers are compact and small capillary-driven heat spreaders that incorporate a cavity in their volume containing a working fluid to provide a high effective thermal conductivity. Numerical simulations and experimental tests revealed that the use of vapour chambers provided significant increase of the output power, with a maximum produced power of 28.2 W and a relative difference of 6.27 W against conventional energy scavenging configurations. Results demonstrate the high thermal cooling performance of vapour chambers to efficiently support thermal energy harvesting solutions designed for condition and structural health monitoring.