Nearly 40% of drugs coming to the market nowadays are having poor solvency related issues and 70% molecules in the discovery pipeline are in effect fundamentally insoluble in water. Nanocrystals is an unmistakable instrument to tackle the issue identified with poor fluid solvency and helps in improving the bioavailability of various drugs as presented in the literature. The particle size reduction came about into the temperamental nanocrystalline system and the phenomenon of ostawald ripening happens. These techniques are preparing to the improvement of nanosized objects, which can play out multiple technological tasks. There are a few couples of noteworthy benefits of nanocrystal formulations, for example, upgrade oral bioavailability, improved dose proportionality, reduced food effects, appropriateness for administration by all routes and probability of sterile filtration because of diminished particle size range. One of the most adequate preferences of nanocrystals is their wide scope of utilization, for example, ophthalmic delivery, oral delivery, transdermal delivery, pulmonary delivery, intravenous delivery and targeted delivery, especially for tumour and brain. The increment in the commercial value of nanocrystals just as the measure of nanocrystal products in the market is picking up more of attention to be utilized as a strategy so as to get commercial advantages. In this paper, a brief and accurate precis of nanosuspension is stated with a specific spotlight on nanosuspension preparation methodologies, benefits and few major applications of nanosuspensions. I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s
Elevated bioavailability is an advantage for most of the poorly soluble drugs. The present scenario of research investigation is concentrated on different techniques to alter the solubility characteristics of weakly soluble drugs and crystallization phenomenon is one amongst them. The low solubility problem can be solved by changing the crystal habit of drug. So, in the present research an attempt has been made to modify the solubility characteristics of Nifedipine, an anti-hypertensive drug, using solvent change method, Solvent evaporation technique and solvent change precipitation technique. Among them solvent change method gave a better formulation (NIF-MC-6) showing better dissolution (91.36% at the end of 240mins) as compared to pure drug and micro-crystals formulated using other methods. The formulated crystals of Nifedipine were subjected to various physicochemical parameters like size distribution, solubility studies, in-vitro dissolution studies, drug content, FT-IR, DSC, crystallographic studies by PXRD and crystal morphology by SEM studies. The micro-crystals produced with PVPK30 and chloroform. FT-IR Results showed that there was no chemical interaction between the drug, solvent and the stabilizer. PXRD of micro-crystals showed higher peak height than pure drug indicating that crystal habit modification occurred in the microcrystals without any polymeric changes and were found to be smaller in size than pure drug and free from any interactions. SEM studies indicated that the crystals are present in rectangular and square shape. The DSC curve showed that Nifedipine appeared an endothermic peak at about 174 0 C corresponding to its melting. However, the crystals prepared with PVP K30 shows shift of endothermic peak towards lower temperature at 170.82 0 C respectively, dictating decreased melting point of the drug in the formed crystals, which accounted for increased solubility of the drugs.
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