The Front Cover shows the inverse‐electron‐demand hetero‐Diels‐Alder cycloaddition between azlactones and α,β‐unsaturated ketones derived from thioisatine. The metal gears shown in the picture directly refer to the aromatization process that constitutes the main driving force of the developed transformation. Artwork by Jan Bojanowski. More information can be found in the Communication by Ł. Albrecht et al.
Aminocatalytic synthesis of highly enantiomerically enriched uracil derivatives bearing a bicyclo[2.2.2]octane scaffold is described. The developed strategy utilizes 1,3,6-trimethyl-5-formyluracil and α,β-unsaturated aldehydes as starting materials and has been realized employing various aminocatalytic activation strategies operating in a synergistic manner. The reaction cascade can be described as doubly cycloadditive as it consists of two consecutive Diels–Alder cycloadditions allowing for a facile construction of the bicyclo[2.2.2]octane scaffold. Notably, both steps proceed with dearomatization of the partially aromatic uracil moiety. Excellent stereoselectivity of the reaction cascade is ensured by the use of 2-(diphenylmethyl)pyrrolidine as aminocatalyst.
The Front Cover shows the inverse‐electron‐demand hetero‐Diels‐Alder cycloaddition between azlactones and α,β‐unsaturated ketones derived from thioisatine. The metal gears shown in the picture directly refer to the aromatization process that constitutes the main driving force of the developed transformation. Artwork by Jan Bojanowski. More information can be found in the Communication by Ł. Albrecht et al.
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