Linear discriminant analysis (LDA) has been widely used for dimension reduction of data sets with multiple classes. The LDA has been recently extended to various generalized LDA methods that are applicable regardless of the relative sizes between the data dimension and the number of data items. In this paper, we propose several multiclass classifiers based on generalized LDA (GLDA) algorithms, taking advantage of the dimension reducing transformation matrix without requiring additional training or parameter optimization. A marginal linear discriminant classifier (MLDC), a Bayesian linear discriminant classifier (BLDC), and a one-dimensional BLDC are introduced for multiclass classification. Our experimental results illustrate that these classifiers produce higher ten-fold cross validation accuracy than kNN and centroid-based classifiers in the reduced dimensional space obtained from GLDA.
Background: The construction of literature-based networks of gene-gene interactions is one of the most important applications of text mining in bioinformatics. Extracting potential gene relationships from the biomedical literature may be helpful in building biological hypotheses that can be explored further experimentally. Recently, latent semantic indexing based on the singular value decomposition (LSI/SVD) has been applied to gene retrieval. However, the determination of the number of factors k used in the reduced rank matrix is still an open problem.
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