Aim. We discuss technical points, the safety, and efficacy of ultrasonic bone shaver in various spinal surgeries within our own series. Methods. Between June 2010 and January 2014, 307 patients with various spinal diseases were operated on with the use of an ultrasonic bone curette with microhook shaver (UBShaver). Patients' data were recorded and analyzed retrospectively. The technique for the use of the device is described for each spine surgery procedure. Results. Among the 307 patients, 33 (10.7%) cases had cervical disorder, 17 (5.5%) thoracic disorder, 3 (0.9%) foramen magnum disorder, and 254 (82.7%) lumbar disorders. Various surgical techniques were performed either assisted or alone by UBShaver. The duration of the operations and the need for blood replacement were relatively low. The one-year follow-up with Neck Disability Index (NDI) and Oswestry Disability Index (ODI) scores were improved. We had 5 cases of dural tears (1.6%) in patients with lumbar spinal disease. No neurological deficit was found in any patients. Conclusion. We recommend this device as an assistant tool in various spine surgeries and as a primary tool in foraminotomies. It is a safe device in spine surgery with very low complication rate.
Background. Recent studies have revealed that inflammatory processes are involved in the pathogenesis of Parkinson's disease (PD). Multiple lines of evidence have suggested that chemokines and their receptors are involved in several neurodegenerative disorders. We have examined whether genetic polymorphisms at the genes encoding chemokines IL-8 (-251A>T), MCP-1 (-2518A/G), and RANTES (-28C>G) and chemokine receptors CCR2 (V64I) and CCR5 (-Δ32) were associated with sporadic PD risk in Isparta, Turkey. Method. The pilot case-control association study included 30 PD patients and 60 control subjects, who were all genotyped with PCR-RFLP for the five polymorphisms. Their genotype and haplotype frequencies were compared statistically. Results. One SNP (-28C>G) in RANTES revealed a significant association with PD (P (allele) < 0.0001, p-trend = 0.0007). The risk allele (G) in the homozygous and dominant models (OR = 17.29 and 32.10, 95% CI = 0.86–347.24 and 1.74–591.937, resp.) suggests additional PD risk. The haplotype TGCAN from the IL-8 (-251A>T), MCP-1 (-2518A>G), RANTES (-28C>G), CCR-2 (V64I), and CCR-5 (-Δ32) has protective effect (OR = 0.08 [CI = 0.01–0.63], p = 0.019). Conclusions. Our data are the first indication of the role of RANTES (-28C>G) in PD risk.
Malignant melanoma caused by malignant transformation of melanocytes is associated with high mortality and is difficult to manage. Metastasis is not uncommon (up to 31% of all cases) and is closely associated with a poor prognosis. Although rare (4-5%), extracutaneous melanoma has been reported; however, primary malignant melanoma of the sacrum is extremely rare (only three case reports to date). Here, we present a 51-year-old patient who underwent surgical treatment for a lesion of the spinal canal and associated bony structures; extensive aggressive resection was required. She underwent partial sacrectomy and lumbo-iliac fixation (to maintain spinal stability). Pathology revealed malignant melanoma. We discuss the diagnosis, surgical intervention, and postoperative follow-up, which may assist clinicians. Although metastatic malignant melanoma is usually fatal, primary extracutaneous melanoma of the spine may respond well to surgery and adjuvant radiotherapy.
Introduction Spinal surgery requires microscopic bone removal, in which high speed drills are used. However, the spinning and increased heat production when drilling with diamond burrs under the microscope may cause damage to the soft tissues such as the dura, nerve roots, the cord and vessels. Ultrasonic bone removers have been introduced to spine surgery recently. We review the clinical application of different types of ultrasonic bone removers in spine surgery and discuss technical points, the safety and efficacy of ultrasonic bone shaver in various spinal surgeries. Material and Methods Between June 2010 and January 2014, 307 patients with various spinal diseases were operated with the use of Misonix ultrasonic bone curette with microhook shaver (MUBS). Patients' demographics, disease type, surgery performed and complications and follow up were recorded. Results Among the 307 patients, 33 (10,7%) cases had cervical disorder, 17 (%5,5) thoracic disorder, 3(0,9%) foramen magnum disorder and 254 (82,7%) cases had lumbar disorders. Hemilaminectomy, limited-extended foraminotomy, revision lumbar disc surgery, corpectomy, osteophytectomy and laminoplasty were performed either assisted-or alone by MUBS. The duration of the operations was comparable with conventional spine surgeries, and the need for blood replacement was relatively low. The one year follow up with Neck Disability Index (NDI) and Oswestry Disability Index Scores (ODI) were comparable with conventional studies. We had 5 cases of dural tears (1.6%) in patients with lumbar spinal disease. Conclusion MUBS does not produce excessive heat and is a useful instrument for procedures performed in narrow epidural spaces near the dura mater. According to our experience; it is also a safe tool with very low complications rates after the learning curve is reached. We recommend this device as an assistant tool in various spine surgeries, and as a primary tool in foraminatomies.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.