Thirty-four thiosemicarbazones and S-alkyl thiosemicarbazones, and some of their Zn(II) and Pd(II) complexes were obtained and purified to investigate antimicrobial activity. MIC values of the compounds were determined by the disc diffusion method against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Staphylococcus aureus, S. epidermidis, and Candida albicans. The thiosemicarbazones show antibacterial and antifungal effects in free ligand and metal-complex form. Picolinaldehyde-S-methyl- and -S-benzylthiosemicarbazones did not affect the tested microorganisms but their Zn(II) complexes showed selective activity. The antimicrobial activity is relatively high in Me2SO, but the antimicrobial potential is changed in a certain range with Me2SO, HCONMe2, EtOH and CHCl3.
The coordination compounds of isatin-thiosemicarbazone (L 1 ) and its Sbenzyl-ester (L 2 ), and of thiophene-2-aldehyde-thiosemicarbazone (L 3 ) and its S-benzylester (L 4 .HCI) with Cu(II), Ni(II) and Fe(III) were investigated via Potentiometrie method.According to the study done by using the Irving-Rossotti technique, the protonization constants of the ligands and the stability constants of the relevant complexes in 50% dmso/water medium were found. The behavior of the isothiosemicarbazone ligands in the solvent medium was evaluated by considering the likely Z-E isomerizations. The preliminary data, which can be and Cu(ll) Complexes useful in tracing the formations of metal compounds according to the Ζ and Ε isomers of isothiosemicarbazones, were obtained by the Potentiometrie method.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.