Objectives. The aim of the study was to identify potential prognostic factors in Hodgkin's lymphoma-HL patients by means of assessment of the influence of mast cells on clinical characteristics of the disease. Patients adn methods. Tryptase-and chymase-positive mast cell density was assessed in order to correlate it with histological type, staging, sex and age of patients. Tissue specimens were taken from a group of 72 patients treated for Hodgkin's lymphoma in the Department of Internal Medicine and Oncological Chemotherapy of the Silesian Medical Academy in Katowice from 1990 to 2002. The analyzed group consisted of 44 men (age 16-73 years, av. 39.2) and 28 women (age 15-73 years, av. 36.5) presenting 5 histological types of HL according to the WHO classification. Overall survival (OS) for the group ranged from 3 to 169 months (av. 64.5) while disease free survival (DFS) was from 4 to 167 months (av. 44.8). Results. The highest MCD-T and MCD-C was observed in NS while the lowest had characterized LD. A statistically significant difference in MCD-T was noted between NS and LD (p=0.0002). Despite the fact that increased MCD-T and MCD-C was observed in stage III of the disease and the lowest in stage IV. No correlation were found between MCD and stage, sex or age. Overall survival was assessed in correlation with the histological type and showed to be the best in MC and the worst in NS. Conclusions. Tryptase and chymase positive mast cell density is related to the histological type of HL. Increased mast cell density correlates with worse prognosis in patients with HL.
Extraskeletal carcinomas with osteoclast-like giant cells (OGC) constitute a rare type of malignant tumors, usually located in the pancreas, gall bladder, breast and kidney. Histologically they are characterized by the presence of multinucleated giant cells that resemble osteoclasts mixed with poorly differentiated adenocarcinoma cells. This paper reports a case of primary gastric adenocarcinoma with osteoclast-like giant cells in a 75-year-old woman who suffered from epigastric pain, nausea, vomiting and weight loss. Histological examination of the tissue obtained during initial surgery (subtotal palliative Billroth II resection) revealed poorly differentiated adenocarcinoma with an infiltrate of osteoclast-like giant cells and no EBV immunostaining (non-lymphoepithelioma-like carcinoma, stage pT4aN3a). The tumor progressed rapidly with extensive perigastric involvement, infiltration of the paraaortic lymph nodes and the head of the pancreas. Poor general condition (WHO 3) prevented postoperative chemotherapy. The patient died 5 months after surgery due to rapid relapse. There is still a lack of knowledge to determine the prognosis for patients with OGC carcinomas. In this study, we report a case of gastric adenocarcinoma with OGC and review the previously published literature clinical and pathologic data on this rare neoplasm.
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