The red cells of two sisters had very weak Cra and Tca antigens and reacted only weakly with the antibody of the Cr(a-) Tc(a-)person, Inab. Both sisters had an antibody, named anti-Dra, to a high frequency antigen absent from their own cells and lnab cells but present on Cr(a-) Tc(a+) and on Cr(a+) Tc(a-) cells. This is the third example in which both Cra and Tca antigens are either absent or show weakened expression on the red cells, but the first case in which t h e unusual phenotype is shown to be inherited. TRANSFUSION 1984;24:13-15.
An IgG antibody defining a high-frequency red cell antigen was detected in the sera of two unrelated, nontransfused black women GT (gravida 1, para 0) and DLC (gravida 4, para 2). Inheritance of the antigen was established by the family study of DLC. The clinical significance of the antibody is not yet known. The antibody has been designated anti-Tca, and the corresponding antigen, Tca. No Tc(a-) individuals were found among 5000 Caucasians, 5000 Japanese, or 450 blacks; however, anti-Tca was identified in the sera of two other unrelated black women (LZ and WM). A relationship between Tca and Cra has been proposed by other serologists, but further evidence is needed to confirm the association.
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