BackgroundHereditary thrombocythemia is an autosomal dominant disorder with clinical features resembling sporadic essential thrombocythemia. Germline mutations in families with hereditary thrombocythemia have been identified in the gene for thrombopoietin (TPHO) and its receptor, MPL.
Introduction. E-learning has been known and used in many countries for a long time.It is becoming more and more popular. It is a way of teaching remotely, using the latestinformation technology. It can be used in any age group, starting with pre-school teaching.In the era of the SARS-CoV-2 pandemic, remote learning has been mandatory due to theneed to continue the teaching process whilst at the same time reducing the risk of spreading the virus. This has revealed many advantages, but also the disadvantages of this type of teaching.Aim & methods. The aim of the work is to change the advantages and disadvantagesof remote teaching as one of the modern forms of education. The work attempts to showthe problems related to the risks and diffi culties associated with distance learning and theadvantages of the development of information technology. We reviewed recent literatureon e- learning in Poland. We supplemented it with our own observations.Results & Conclusions. Reviewed empirical studies from Poland suggest that the mainadvantages of distance learning are professional development of teachers, intergenerational experience exchange, time saving, the possibility of learning at a pace adapted tothe student, access to a large quantity of teaching materials as well as the development andexpansion of IT infrastructure. The main disadvantages are lack of peer interactions, theneed to spend a lot of time in front of the computer, lack of physical activity, diffi culties inindependent assimilation of new material, lack of direct contact with the teacher, lack ofcomputer equipment and inadequate housing conditions, lower didactic effects, social andeconomic exclusion.E-Learning is an excellent form of learning, due to its many advantages such as timesavings and access to a wide range of materials, but requires a lot of commitment from thelecturers to encourage students to expand their knowledge and on the part of students selfcontrol and motivation.
We investigated the prevalence of the JAK2 V617F gain-of-function mutation in patients with Philadelphia chromosome-negative chronic myeloproliferative disorders (Ph- MPD) and explored the links between JAK2 mutational status and the clinicopathologic picture of essential thrombocythemia (ET), chronic idiopathic myelofibrosis (CIMF), and polycythemia vera (PV). Allele-specific polymerase chain reaction results for 59 ET, 18 CIMF, and 9 PV cases were compared with values for clinical variables at presentation and last follow-up and with the diagnostic trephine bone marrow biopsy pictures. JAK2 V617F was found in 38 (64%) of ET cases, 7 (39%) of CIMF cases, and 9 (100%) of PV cases. The ET patients with the mutant JAK2 showed significantly higher (although not overtly polycythemic) red blood cell parameter values, lower platelet counts, and higher white blood cell counts. Similar trends were found in CIMF. Megakaryocyte clustering was much less pronounced in the CIMF cases with mutant JAK2, with an analogous trend occurring in the ET cases. Bone marrow cellularity values and the numbers of CD34+ and CD117+ blasts in the ET and CIMF groups did not differ. Fibrosis was slightly less marked in the ET cases with mutant JAK2. The mutation did not significantly influence the clinical course during the follow-up in either disease in the short term (median follow-up, 22 months). The JAK2 V617F mutation is prevalent in all Ph- MPD and may skew their presenting phenotype, including bone marrow histology, toward a more "erythremic" and less "thrombocythemic" phenotype.
Introduction: Living in the age of modern inventions one forgets about one of the best medications for many health problems, which is physical activity. In 2016, Kantar Public (Ministry of Sport and Tourism, 2016) announced that only one in five Poles aged 15-69 had an adequate level of physical activity. A CBOS (Centre for Public Opinion Research) survey conducted in 2014 showed that half of Poles weigh too much. For the development of lifestyle diseases, besides overweight, the wrong lifestyle also contributes (CBOS No. 122/2014). According to the WOBASZ (a multi-center nationwide survey of the health status of the population) survey, only 3% of Polish society is characterized by "an indicator of a healthy lifestyle" (Kwaśniewska, Kaczmarczyk-Chałas, Dziankowska-Zaborszczyk, Kucharczyk, Drygas, 2010). The role and task of physical activity at an early age, as well as at any other stage of life, is very important in the prevention of civilization diseases, which is why it is crucial to monitor it. Aim of the study: The aim of the study was to assess the relationship between the level of physical activity, state of health and the lifestyle of the academic youth. Material and methods: The research was carried out among students from three universities in Wrocław (n = 629): University of Wrocław (UWr), Wrocław University of Science and Technology (PWr) and Wrocław Medical University (UM). The study used self-constructed questionnaires: physical activity questionnaire, health questionnaire, lifestyle questionnaire. The following statistical analyzes of the results were used: Shapiro-Wilk test, Pearson chi-square test independence, post-hoc test, analysis of variance (ANOVA), correlation coefficient rank (Spearman) and Pearson's correlation coefficient. In the calculations, the package of computer programs STATISTICA v. 9.0 was used. Hypotheses verified at the level of p ≤0.05. Results: Health was the highest-rated one of the studied factors. In addition, it was found that as much as 67.7% of students from all universities represent a very good level of lifestyle. 68.4% of the respondents were characterized by a very good health potential. Research has shown that the physical activity of students from Medical University is at a higher level than students of PWr and UWr. Among the demographic variables, gender turned out to be important (men perform physical activity more often than women, while BMI and place of origin did not affect the physical activity of students). Studies have confirmed the relationship between all major variables (physical activity, lifestyle and health). The increase in the level of physical activity is accompanied by an increase in the level of lifestyle. A positive correlation between lifestyle factor and health condition was also observed.
Wprowadzenie. Aktywność fizyczna stanowi kluczowy i integrujący składnik zdrowego stylu życia. Cel pracy. Ocena poziomu aktywności fizycznej studentów w zależności od typu uczelni, płci i miejsca zamieszkania. Materiał i metody. Przebadano 629 studentów z trzech wyższych uczelni we Wrocławiu: Uniwersytetu Wrocławskiego, Politechniki Wrocławskiej oraz Uniwersytetu Medycznego. W badaniach użyto Międzynarodowy Kwestionariusz Aktywności Fizycznej IPAQ-wersja krótka. W obliczeniach korzystano z pakietu programów komputerowych STATISTICA v. 9.0. Zastosowano test niezależności chi² Pearsona. Wyniki. 37,3% studentów uzyskało wysoki poziom aktywności fizycznej, 26,0%-wystarczający, 36,7%-niski. Wysoki poziom istotnie częściej deklarowali studenci Politechniki Wrocławskiej od studentów Uniwersytetu Wrocławskiego (50,7% vs 27,7%; p < 0,001) i Uniwersytetu Medycznego (50,7% vs 33,0%; p < 0,001). Niski poziom aktywności deklarowali istotnie rzadziej studenci Politechniki od studentów Uniwersytetu Wrocławskiego (19,3% vs 51,4%; p < 0,001) i studentów Uniwersytetu Medycznego (19,3% vs 40,3%; p < 0,001). Wysoki poziom aktywności fizycznej uzyskało 38,1% kobiet i 36,6% mężczyzn. Niski poziom prezentowało 34,3% kobiet i 39,1% mężczyzn. Wysoki poziom aktywności fizycznej osiągnęło 38,7% studentów mieszkających na wsi i 36,9% studentów pochodzących z miasta. Wnioski. 1. Płeć nie ma wpływu na poziom aktywności fizycznej studentów. 2. Wysoki poziom aktywności fizycznej występuje częściej u studentów Politechniki Wrocławskiej niż u studentów Uniwersytetu Wrocławskiego i Uniwersytetu Medycznego. Niski poziom aktywności ruchowej najczęściej występuje u studentów Uniwersytetu Wrocławskiego. 3. Miejsce pochodzenia studenta nie ma wpływu na jego aktywność ruchową.
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