Iminium ions are known to exist only transiently in aqueous solution due to their high reactivity toward hydrolysis. In this communication, we report on the generation and stabilization of iminium ions in aqueous solution via molecular encapsulation using a K12Ga4L6 host. Our studies revealed that tetrahedral host 1 can encapsulate a variety of iminium cations in a molecular recognition process that is selective based on the charge, hydrophobicity, size, and shape of the guest.
Das ortsselektive Einbringen (gelb) eines Elektrons in Thymin mithilfe des modifizierten Nucleotids 1 (1→2) wurde zur Untersuchung der Distanzabhängigkeit des Überschusselektronentransfers in DNA genutzt. Das Elektron katalysiert die Spaltung der DNA an einem Thymindimer (rot) und konnte mehrere UV‐induzierte Läsionen in der DNA 3 reparieren.
Electron-catalyzed repair of thymine dimers in double-stranded DNA is described by B. Giese, T. Carell, O. Schiemann, and co-workers on page 1848 ff. Transport of an electron from a remote modified thymine base through DNA occurs in a multistep hopping process. When the electron meets a thymine dimer, which is generated by photocycloaddition of adjacent thymine residues, the two thymine bases are repaired through a retro-cyclization reaction, while the electron continues along the DNA.
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