Summary, The effect of ketone bodies on ihe growth, in culture, of transformed lymphoblasts (Raji cells) was investigated. Cell growth was inhibited and this efTect was reversible, non-toxic, and proportional to the concentmtion of D-j^-hydroxybutyrate up to 20mM. The total glucose utilisation and the total lactate production were reduced in proportion to the inhibition of cell proliferaiion. D-^-hydroxybutyrate was not metabolised by the eells. Other glycolytic inhibitors and chemical analogues of f5-^-hydroxybutyrate either did not inhibit or proved to be too toxic for cell growth. D-/?-hydroxybutyrate also inhibited the growth of rabbit kidney (RK13), HeLa, mouse melanoma (BIft), fibroblast and trypsin-dispersed human ihyroid and beef tcstis cells. Moreover, in vivo dietary-induced ketosis redticed the number of B16 melanoma deposits in the lungs of C57BL/6 mice by two-thirds. The sinnificunce of these results in the clinical management of cancer cachexia is discussed.
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