The Chinese materia medica Xianmao (XM) is widely used in Chinese clinics and the traditional Chinese medicine diets. Although XM is often used to study its kidney‐yang effect, the research on its effect on kidney energy metabolism and its mechanism is still relatively lacking. In this study, rats were given different doses of XM water extract for 4 weeks. Biochemical method was used to detect the content of serum biochemical indexes of liver and kidney function and blood lipid indicators, and HE staining method was used to observe the histopathological of liver and kidney in rats. The kidney Na+‐K+‐ATPase, Ca2+‐Mg2+‐ATPase, SDH (succinate dehydrogenase) enzyme activity, and the content of ATP in rats were measured. Metabolomics technology was used to analyze the potential biomarkers related to the effects of XM on kidney energy metabolism, and then, the metabolic pathways were analyzed. RT‐PCR was used to detect the expression of Ampk, Sirt1, Ppar‐α, and Pgc‐1α mRNA in kidney of rats. The results showed, compared with the blank control group, there was no significant effect on liver and kidney function in XMH, XMM, and XML groups. These significantly increased the kidney Na+‐K+‐ATPase, Ca2+‐Mg2+‐ATPase, SDH enzyme activity, and ATP content in XMH, XMM, and XML groups. Mitochondrial metabolic rate was inhibited in XMH group, but it was significantly increased in XMM and XML groups. The number of mitochondria was increased in XMH, XMM, and XML groups. Overall, these effects may be mediated by TCA cycle metabolism, butanoate metabolism, propanoate metabolism, alanine, aspartate, and glutamate metabolism, retinol metabolism, purine metabolism, pentose phosphate metabolism, aminoacyl‐tRNA biosynthesis, valine, leucine, and isoleucine biosynthesis, and degradation metabolism pathways, as well as by increasing expression of upstream genes Ampk, Sirt1, Ppar‐α, and Pgc‐1α mRNA.
Reverse circulation (RC) drilling technology enables the rapid acquisition of coal seam samples, which is crucial in accurately measuring gas content. In addition, the design of the drill bit plays a key role in RC sampling. In this study, the turbulence model and simulation method applied during the RC drilling process is analyzed, and an annular jet flow bit is developed. An experimental laboratory setup is used to simulate the RC performance of the proposed drill bit, based on which an orthogonal design simulation of the structural parameters of the drilling bit studies was performed to investigate the effects of the RC drilling process. The experimental results show that annular jet flow moving up the central channel wall of the bit is conducive to the suction of annular airflow and results in the strong flow field created by the center channel of the bit generating negative pressure in the center channel of the bit, a comparison of the computational fluid dynamics data on negative pressure and suction rate shows that the annular jet flow RC bit is suitable for use in RC drilling.
By means of finite element analysis and topology optimization methods, the structural optimization and lightweight design of the robotic arm for the installation of gas drainage pipelines are realized, so that it can realize more complex actions under the premise of ensuring stability. SolidWorks 3D modeling and Ansys Workbench analysis software are used to build models of the robotic arm and perform static analysis. The structural design is optimized through the deformation and stress distribution when grasping the maximum weight. The topology optimization mathematical model of the variable density method and the SIMP (Simplified Isotropic Material with Penalization) interpolation model was constructed, and the topology optimization of the robotic arm was performed in the Shape Optimization module in Ansys Workbench. On this basis, the structure after topology optimization is analyzed and studied. The results show that compared with before topology optimization, the mass of the manipulator is reduced by 29.65%, and the maximum deformation and maximum stress are both reduced by 10%, which confirms the feasibility of lightweight design and structural optimization of the manipulator.
Objective. We explored changes in heart rate during the peri-ictal period in patients with focal epilepsy, and differences in heart rate changes according to epileptic site and side were assessed. Methods. A total of 198 epileptic seizures in 102 patients with focal epilepsy, who had a definite epileptogenic focus and had undergone surgical treatment, were assessed from 2014 to 2019. Heart rate was measured manually during the peri-ictal period. Change in heart rate and the time it occurred were assessed and compared between different epileptic sites and sides. Results. Heart rate increased in 177 (89.4%) of 198 seizures. In 82 (44.8%) of 183 seizures, the change in heart rate occurred before seizure onset. The median period of heart rate change was seven seconds (interquartile range: 3-11 seconds) in seizures with heart rate change before seizure onset. The number of seizures with heart rate increase before seizure onset was significantly greater for medial temporal lobe epilepsy compared to lateral temporal lobe epilepsy (p=0.019) and extratemporal lobe epilepsy (p=0.002). Significance. A change in heart rate prior to seizure onset is more likely to occur in patients with medial temporal lobe epilepsy, compared to those with lateral temporal lobe epilepsy and extratemporal lobe epilepsy. Patients with medial temporal lobe epilepsy may likely benefit from seizure warning and detection devices.
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