Eight new 2D isostructural lanthanide coordination polymers (Ln-CPs), [Ln(HL)(HO)(NO)]·NO (1-Ln), Ln = Nd, Sm, Eu, Gd, Tb, Dy, Ho, and Yb ions, HL = 4-(3,5-dicarboxylphenyl)-2-methylpyridine, were synthesized by using solvothermal methods and studied by structural analyses, magnetic analyses and luminescent probes. Crystallographic studies revealed that these compounds are 2D frameworks in which dinuclear units with double μ-syn,syn-carboxylate bridges are interlinked by single μ-trans,trans-carboxylate bridges from organic spacers. The layers are further stabilized and combined into 3D architectures through intra- and interlayer ππ stacking interactions and hydrogen bonding, respectively. Magnetic investigations indicated that the carboxylate bridges transmit intralayer antiferromagnetic coupling in 1-Nd, 1-Gd and 1-Ho but transmit intralayer ferromagnetic coupling in 1-Dy. Furthermore, 1-Dy also displays slow magnetic relaxation behavior with a high relaxation energy barrier (ΔU) of 100.7 K and a pre-exponential factor (τ) of 1.4 × 10 s under zero dc field. The luminescence investigations showed that CPs 1-Eu and 1-Tb can serve as highly selective and recyclable sensing materials for Fe, CrO and nitrobenzene. Thus, both 1-Eu and 1-Tb should be excellent candidates for multifunctional sensors.
Objective To explore underlying mechanisms that regulate hMSH2 expression and drug susceptibility in epithelial ovarian cancer (EOC). Methods Using data from the Cancer Genome Atlas (TCGA) we used bioinformatical analysis to predict transcription factors (TFs) that potentially regulate hMSH2. RT-qPCR, Western blot, and luciferase assays were undertaken using ovarian cancer cell lines to verify the identified TF. Expressions of the TF were modulated using overexpression or knockdown, and the corresponding cellular responses to cisplatin were examined. Results The TF, E2F1, was found to regulate the hMSH2 gene. The expression level of E2F1 correlated with cisplatin susceptibility in vitro. Kaplan-Meier analysis of 77 patients with EOC showed that low E2F1 expression was associated with worse survival. Conclusions To our knowledge, this is the first report of E2F1 regulated MSH2 expression playing a role in drug resistance of platinum-based treatments for patients with EOC. Further work is need to confirm our results.
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