A AgSCF3/Na2S2O8-promoted
trifluoromethylthiolation/cascade cyclization of o-propargyl arylazides (or o-alkynyl benzylazides)
triggered by a carbon–carbon triple bond is reported. This
strategy provides the synthesis of valuable SCF3-substituted
quinoline and isoquinoline systems via the construction of one C(sp2)–SCF3 bond and one C–N bond within
one process.
A simple protocol for the UV light irradiated preparation of heteroaryl trifluoromethyl thioethers from disulfides and inexpensive, environmentally sodium triflinate (CF3SO2Na) has been developed. The features of simple and clean reaction conditions, in moderate to good yields, and broad substrate scope render this new approach synthetically attractive for the preparation of potentially pharmaceutically active compounds.
An efficient desulfurization C–O coupling reaction of 3,4-dihydropyrimidine-2(1H)-thiones (including thioureas) with alcohols was developed under electrochemical oxidation conditions. Herein, transition-metal catalysts and additives are not required and the alcohol is both the solvent and the alkoxy donor.
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