Background: Intrahepatic cholestasis of pregnancy has been associated with adverse fetal and neonatal outcomes. The objective of this study was to assess the improvement in fetal and neonatal outcomes with timely intervention in pregnant females with intrahepatic cholestasis of pregnancyMethods: This prospective observational study included 50 patients attending antenatal clinic of the Department of Obstetrics and Gynecology of Dr. RML Hospital, from 1st November 2015 to 31st March 2017, using inclusion and exclusion criteria. History, examination, blood investigations, with ultrasound upper abdomen was done for all the patients. Diagnosed patients were treated accordingly and fetal and neonatal outcomes were studied. The data was analyzed using STATA (version 13.1, Stata Corp 4905 Lakeway Drive College Station, Texas 77845 USA). Comparisons were analyzed using Chi-Square, Student’s t-tests.Results: In the present study, in view of timely diagnosis and intervention, 82% of the neonates had birth weight >2.5kg. 94% of the total neonates had >7 APGAR at 1min, and 100% of the neonates had >7 APGAR at 5min. No stillbirth was observed in present study group. No NICU admission was observed in the present study.Conclusions: Patients with intrahepatic cholestasis of pregnancy should be taken with utmost care. With early intervention, the adverse effects on fetus and neonates can be reduced to a significant amount.
Background: The aim of the study was to determine association of abnormal lipid profile in early second trimester (14 to 20 weeks) with development of pre-eclampsia.Methods: A prospective observational study included 260 women between 14-20 weeks of pregnancy attending a tertiary care Hospital in New Delhi. Serum lipid profile analysis was performed at the time of enrolment and cohort was followed up for occurrence of pre-eclampsia till 48 hours after delivery. Outcomes measured were difference in mean lipid levels in study (abnormal lipid profile) and control group (normal lipid profile) and accuracy of abnormal lipid profile to predict pre-eclampsia.Results: The incidence of pre-eclampsia in our study was 11.13%. The mean serum total cholesterol was significantly higher in pre-eclampsia group (199.74 mg/dl vs 171.7 mg/dl; p<0.05). The difference in mean triglyceride, HDL, VLDL and LDL levels between two groups was not significant. Total cholesterol has 44.83% sensitivity, 84.85% specificity, 27.08% PPV, 92.45% NPV with diagnostic accuracy of 80.38% in predicting pre-eclampsia (with 0.65% AUC with 95% confidence interval). While VLDL has maximum sensitivity of 68.97% while HDL has maximum specificity of 86.15% in predicting pre-eclampsia.Conclusions: Abnormal total cholesterol levels have diagnostic accuracy of 80.38% to predict pre-eclampsia and abnormal lipid profile in early second trimester is a simple, non-invasive and economical test for prediction of pre-eclampsia.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.