A catalytic protocol for "CF 3 "-radical type addition to terminal and β-substituted olefins with Togni's reagent to deliver various αtrifluoromethylated ketones of biomedicinal interests was examined by a series of oxovanadium species under oxygen atmosphere at ambient temperature. Among six different V(O)X 2 bearing (bi)pyridine, imidazole, and (bis)oxazoline ligands and five different oxidovanadium complexes derived from N-salicylidene tert-leucinate, and salen ligands examined, the complexes with 3,5-dibromo substituents and VO(OTf) 2 with bisoxazoline type ligands led to the best results.
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