Epidemiological reports have indicated a correlation between the increasing bisphenol A (BPA) levels in the environment and the incidence of male infertility. In this study, the protective effects of melatonin on BPA-induced oxidative stress and apoptosis were investigated in the rat testes and epididymal sperm. Melatonin (10 mg/kg body weight (bw)) was injected concurrently with BPA (50 mg/kg bw) for 3 and 6 weeks. The administration of BPA significantly increased oxidative stress in the testes and epididymal sperm. This was associated with a decrease in the serum testosterone level as well as sperm quality, chromatin condensation/de-condensation level, and the percentage of haploid germ cells in the semen. BPA administration caused a significant increase in apoptosis accompanied by a decrease in the expression of the antiapoptotic proteins Bcl-2 in the testes and epididymal sperm. The concurrent administration of melatonin decreased oxidative stress by modulating the levels of glutathione, superoxide dismutase, and catalase as well as the malondialdehyde and hydrogen peroxide concentrations in the testes and sperm. Melatonin sustained Bcl-2 expression and controlled apoptosis. Furthermore, melatonin maintained the testosterone levels, ameliorated histopathological changes, increased the percentages of seminal haploid germ cells, and protected sperm chromatin condensation process, indicating appropriate spermatogenesis with production of functional sperm. In conclusion, melatonin protected against BPA-induced apoptosis by controlling Bcl-2 expression and ameliorating oxidative stress in the testes and sperm. Thus, melatonin is a promising pharmacological agent for preventing the potential reproductive toxicity of BPA following occupational or environmental exposures.
Background Sage and ginger are considered from the medicinal and aromatic herbs and as a treatment method in traditional medicine a variety of diseases and is also used as a spice for cooking. Methodology The treatments were divided into three groups for each extract of the plant extracts of sage and ginger. The first group was dosed with sage extract at the rate of 0.5 ml per day for thirty days and the second group with alcoholic extract after disposal, of alcohol in the same quantity and the latter was left without a control dose. The same process was repeated on the ginger plant, then the blood was drawn and the amount of sugar was measured in all the groups Blood was drawn a month after the mice were infused with plant extracts, and some tests were conducted that included checking blood sugar, cholesterol, triglycerides, urea and creatinine. The present study showed significant decrease in the level of blood sugar between 60 to 64 mg/100 for ginger plant and sage aqueous extract respectively, compared to the control group 110 mg/100 ml. Ginger and sage aqueous extract also significantly reduced the level of urea in the blood to 18.21 mg /100 ml compared to the control 40 mg / 100 ml. The present work found that both sage and ginger have a vital role in the treatment of various damage and diseases. This may well be a type of treatment as drug role.
Environmental pollution had been a reality of life for several centuries however it became a true drawback since the beginning of the commercial revolution. Environmental contaminants are shown to induce ROS generation in each intra-and animate thing areas of cells or people resulting in cell death and tissue injury. Chemicals that induce effects by uncomfortable endocrine systems or mimicking endocrine mediators are jointly delineated as endocrine disrupting compounds (EDCs).Bisphenol A, (BPA) (2, 2-bis (4-hydroxyphenyl) propane) is one in every of the world's highest production volume compounds. It a phenolic compound and is wide utilized in the assembly of resins and polycarbonate plastics. Earlier, it's been shown that BPA induced oxidative stress in numerous tissues in human and rats. This study investigates the results of Bisphenol A pollution on Lipids profile, glucose level, antioxidants and therefore the potential pollution protection by melatonin in experimental. The rats received ten mg/kg of internal secretion pursued by 50 mg/kg of Bisphenol A 3 days per week for 6 incontestable increase triglycerides, total cholesterol, LDL and VLDL, illustrate important in cluster treated with BPA for three and 6 weeks cluster. These were related to the enlarged in lipid peroxidation and cut inhibitor glutathione, superoxide dismutase, enzyme activity and increase in malondialdehyde levels. The protection by internal secretion was determined in connection with the rejuvenation of all oxidative parameters within the blood serum, suggesting that internal secretion is employed for management of many diseases, like avoirdupois, diabetes, cancer, and immune and cardiac disorders. It will recapture ROS by its antioxidant qualities and raise antioxidant enzyme activities.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.