N-acetylcysteine (NAC) is an anti-oxidantdrug that has been used as a mucolytic agent and a paracetamol antidote for many years. This study was designed to determine the efficacy of the adjunctive use of NAC for periodontal treatment. Thirty subjects with moderate-to-severe chronic periodontitis were randomized to surgery with NAC (600 mg; S-NAC), surgery only (S-nonNAC), and healthy control groups. Gingival crevicular fluid (GCF) samples were obtained from all patients and sRANKL levels were determined by enzyme-linked immunosorbent assay at baseline, and 1, 3, and 7 months post-surgery. Plaque and gingival indices, probing depths, and clinical attachment levels were recorded at the same time. There was a significant reduction in probing depth at 3 months in the S-NAC group when compared to the S-nonNAC group (P < 0.05). However, no statistically significant differences in plaque and gingival indices, probing depths, clinical attachment levels, and sRANKL levels in GCF were noted between the surgical treatment groups at the end of 7 months. Hence, the use of adjunctive NAC resulted in a significant reduction in probing depths in the S-NAC group when compared to the S-nonNAC group at 3 months, but no statistically significant differences in GCF sRANKL levels were observed in the sites that underwent surgical treatment with or without NAC at different time intervals.

The novel coronavirus 2019 (COVID‐19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused an unprecedented healthcare crisis. SARS‐CoV‐2 gets access into the human body mainly through the nose and the mouth and invades these mucosae in its destination to the pulmonary tissues. Thus, the oral and nasal mucosae serve as the main routes and reservoirs for aerosolized transmission of the viral particles to the external environment and hence infection transmission. Statins have been shown to have antimicrobial, antiviral, antifungal, anti‐inflammatory, immunomodulatory, and antioxidant properties. Therefore, we hypothesize that using statins-based prophylactic mouthwashes will reduce COVID‐19 transmission in dental settings.

Introduction: This study sought to assess the efficacy of N-acetyl cysteine (NAC) in treatment of recurrent aphthous stomatitis (RAS).Methods: Fifty eight patients, aged 28±9.7 years, presented with clinically diagnosed RAS to two oral medicine centres. They were assigned randomly to a single application of either NAC (200 mg dissolved in water, n=38) or 0.12% chlorhexidine digluconate (CHX, n=20) mouthwashes for 30 seconds. Pain was measured using a Visual Analogue Scale (VAS). The size of the ulcer was measured through its greatest dimension using a periodontal probe. These two measurements were taken preapplication (day 1) and 2nd, 4th, and 6th day post-application. Average time (in days) until complete healing was assessed.Results: Of all participants, 33 (57%) were females; 34 (59%) married; 29 (50%) reported a family history of aphthae; and 51 (88%) were affected with minor RAS. There were greater improvement in pain from day 1 with NAC on the second day (-3.0 ± 2.0 versus -1.8 ± 1.9; P = 0.028) and on the fourth day (-5.0 ± 2.6 versus -3.4 ± 2.7; P = 0.041). The differences with regard to the change in ulcer size and average healing time were not significant between NAC and CHX. Conclusion:Single-application of NAC results in a clinically significant reduction of RAS-associated pain within one day of application and is more effective than CHX.

Aims:To investigate the relationship between tooth loss, age, gender, and its correlation with several local habits that affect oral health, especially the khat, and Shammah use. Materials and methods: The current study included 580 participants. They were divided into five age groups15-24, 25-34, 35-44, 45-54, and 55-64-years-old. Clinical and radiographic examinations were done for each subject. Reasons for teeth loss, age, gender, khat chewing, Shammah use, smoking, and use of oral hygiene aids were recorded. The data were statically analyzed using Chi-square tests of the statistical package for social sciences (SPSS) program. The p value < 0.05 were considered statistically significant. Results: Caries was the most cause of tooth loss in the young age groups 15-34 years-old and was significantly more common compared to the older groups (p < 0.001). The periodontal diseases increased with age and progressively became the main cause of tooth loss of 100% in the 55-64 years-old group. Orthodontic reasons for tooth extractions were limited to the young age group 15-24 years old. Third molars were the highest extracted teeth in the maxillary arch, while the first molars were the highest in the mandibular arch. Anterior teeth were the lowest extracted teeth ranging from 9; 1.6% in maxillary teeth and 9-29; 1.6-5% in the mandibular teeth. Conclusion: This study highlights the importance of local habitual use of khat 52.9% and Shammah 8.1% besides smoking in tooth loss. Caries was the main cause of tooth loss in the young age groups, followed by the periodontal disease in the older age. Molars were frequently extracted followed by maxillary first premolars. Clinical significance: Limited number of epidemiological surveys were carried out in Taiz Governorate to investigate the reasons of tooth loss and its relationship with social habits like Khat chewing, Shammah use, smoking, using of Miswake and toothbrush. The results of this study will guide us to develop a preventive program which may minimize tooth loss and its adverse effects.

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