We described clinical course and outcome of a patient with Listeria monocytogenes meningitis and rhombencephalitis (RE). A 65-year-old woman with past medical history of chemotherapy and radiotherapy for cervical cancer applied to emergency room with the history of fever and headache for three days. Clinical course indicating meningitis evolved to RE over time. We present this case because of the significance of early diagnosis and adequate antimicrobial therapy targeted to the pathogen. At the end, we suggested an algorithm for the case management.
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