nnnn The aim of this study was to identify the effects of cyclooxygenase (COX)-1 and -2 inhibition each on insulin sensitivity in healthy subjects. A randomized, double-blind, controlled clinical trial was carried out in 21 young, healthy, non-obese male volunteers. Pharmacological COX-1 inhibition was performed with the prescription of acetylsalicylic acid (ASA) at a low dose, and COX-2 selective inhibition was performed with celecoxib. After randomization, all subjects received an oral morning dose of ASA 100 mg (n = 7), celecoxib 200 mg (n = 7), or placebo for the control group (n = 7) during a period of 15 days. Before and after of the study period, a metabolic profile was measured in all participants. An insulin tolerance test (ITT) was performed to assess insulin sensitivity, and the constant for the serum glucose disappearance rate (K ITT) was calculated. Clinical and metabolic characteristics were similar between groups. The K ITT calculated with the ITT was higher after celecoxib than at baseline (4.8 0.9 vs. 4.3 0.6 %/min, p = 0.04), indicating improvement in insulin sensitivity. Neither ASA nor placebo administrations modified insulin sensitivity. In conclusion, COX-2-selective inhibitor at a celecoxib dose of 200 mg daily increased insulin sensitivity in healthy subjects.n
The aim of this study was to compare metabolic profiles and serum leptin concentrations between young insulin-sensitive and insulin-resistant subjects. A cross-sectional study was performed in 32 healthy, non-obese, young volunteers. Assessing of insulin sensitivity, serum leptin concentration, serum uric acid, creatinine levels and lipid profile were done on all subjects.An insulin suppression test modified with octreotide was performed to assess insulin sensitivity. Steady state glucose (SSG) and steady state insulin concentrations were calculated. Based on the SSG data, the volunteers were divided into four quartiles, considering as insulin-sensitive individuals those from quartile 1 to quartile 3, and insulin-resistant subjects those in quartile 4. Characteristics of both groups were compared, including metabolic profile and leptin levels. After dividing SSG into quartiles, 24 subjects were considered as insulin-sensitive individuals, and 8 were assessed as insulin-resistant subjects. Total cholesterol and low-density lipoprotein (LDL) cholesterol were significantly higher in the insulin-resistant group than in the insulinsensitive group. Serum leptin concentration was significantly higher (p=0.05) in insulin-resistant women (6.1 nglml) than those considered as insulin-sensitive (3.7±2.3ng/ml). In conclusion, insulin-resistant subjects had higher concentrations of total cholesterol and LDL-cholesterol compared to insulinsensitive individuals. Serum leptin level was higher in insulin-resistant women than those considered as insulin-sensitive.
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