Objective To evaluate salivary progesterone as a predictor of early preterm birth (PTB) and compare it with transvaginal sonographic (TVS) cervical length in asymptomatic high-risk women.Design Prospective study.Setting Departments of Obstetrics and Gynaecology and Biochemistry at UCMS & GTBH, Delhi, India.Sample Ninety pregnant women.Methods The progesterone concentration in saliva of asymptomatic pregnant women at high risk for preterm delivery was estimated by immunoassay, and cervical length was measured by TVS, at the first antenatal visit at 24-28 weeks of gestation, and then repeated 3-4 weeks later.Main outcome measures Early PTB, mean and critical cut-off values of salivary progesterone, and a diagnostic value comparison of salivary progesterone with TVS cervical length.Results The mean value of salivary progesterone was significantly lower in all women who delivered at <37 weeks of gestation (n = 38), compared with the term group (n = 52; P < 0.001). Salivary progesterone decreased significantly from the first to the second visit, with the maximum decrease observed in women who delivered at <34 weeks of gestation (29.6%, 95% CI 17.8-41.4%, P < 0.002). The single predictive critical cut-off value for salivary progesterone was 2575 pg/ml, below which more than 80% of women delivered prematurely before 34 weeks of gestation, with sensitivity, specificity, and positive and negative predictive values of 83% (95% CI 58.6-96.4%), 86% (95% CI 75.9-93.1%), 60% (95% CI 38.6-78.8%) and 95% (95% CI 87.1-99.0%), respectively. The TVS cervical length decreased significantly (P < 0.001) in the women who delivered prematurely.Conclusions Low salivary progesterone concentration can be used for predicting early PTB in asymptomatic high-risk women.

<p class="abstract"><strong>Background:</strong> To study the clinical and epidemiological pattern of occurrence of non-venereal genital dermatoses among the patients attending STI clinic. Also an attempt was made to know the level of awareness among the patients studied and the level of psychological impact on the affected persons before they were diagnosed as anon venerealdermatoses.</p><p class="abstract"><strong>Methods:</strong> A study was conducted among 125 patients who attended the STI Clinic in a tertiary care center in a period of 6 months. Detailed history was taken along with complete physical examination and local examination.<strong></strong></p><p class="abstract"><strong>Results:</strong> 125 patients attended the STI Clinic. Among them 75 patients [40 males and 35 females] were diagnosed to have Non venereal genital dermatoses. A total of 14 different non venereal dermatoses were observed in our study The commonest age group affected were in the age group of 30-40 year. The most common non-venereal dermatoses in females in our study were Lichen sclerosuset atrophicus and in males were fixed drug eruptions Pearly penile papules. Mild anxiety and concern about the genital lesions were found in almost all the males and females.</p><p><strong>Conclusions:</strong> A prompt and correct diagnosis of non-venereal genital dermatoses needs a greater clinical acumen along with various investigative methods Patient must be treated as a whole rather than treating the disease alone. The complete successful outcome lies not only in treating the disease but also treating the patient as a whole allying his undue fears, stress and misconceptions. </p>

To prevent the public from pandemic Covid’19 the government of India has started the vaccination from mid of January 2021. The government has approved the two vaccines, Covishield from the university of Oxford and Covaxin from Bharat Biotech.The vaccination started with frontline workers and is further extended to common public prioritizing the elders of above 60 years and people aged 45 years above with co morbidities. Though many people have got benefitted from it there is still a group of people not convinced with the vaccination. We have carried out this work to analyze those Indian people sentiments on the vaccines through the hash tags of tweets. The results show that though majority of the community has a positive belief on the vaccines but some of them still express negative emotions.