The Al3+ sensor, 7‐nitrobenz‐2‐oxa‐1, 3‐diazole (NBD) derived fluorescent probe 2‐((E)‐(4‐(phenylamino)benzo[c][1,2,5]oxadiazol‐7‐ylimino)methyl) phenol (3) was synthesized and characterized by various spectral methods and crystallography. The compound (3) exhibits dual channel (fluorometric and colorimetric) sensor behaviour. It has high selectivity for Al3+ detection, produced significant fluorescence enhancement in the presence of Al3+ ion. It shows ‘‘turn off–on’’ fluorescent responses toward Al3+ in semi aqueous medium. Here, the correlative the properties of a photo sensor (NBD based schiff‘s base 3 with normal NBD derivatives 1, 2) towards Al3+ was studied. The solvent effect and cation sensing properties were investigated from ultraviolet spectroscopy and fluorescence spectroscopic methods. The facile synthetic probe 3 will alternative and open new opportunities in bio‐imaging of Al3+ in various cell lines. This will certainly be helpful in understanding the fundamental mechanism of aluminium‐induced human diseases.
The fluorescent probes 7‐nitro‐N‐phenylbenzo[c][1,2,5]oxadiazol‐4‐amine (1), and 4‐((7‐nitrobenzo[c][1,2,5]oxadiazol‐4‐yl)amino)benzonitrile (2) were synthesised for the detection of cyanide ion (CN−). A new correlative approach with nitrobenzoxadiazole (NBD)‐based probes to detecting CN− by the Donor‐Acceptor D‐A (1) and Acceptor‐Donor‐Acceptor (A‐D‐A) (2) with the aid of DFT calculations are reported. Given their design features, these NBD probes 1 and 2 provide useful insights into the dual‐channel (fluorometric and colorimetric) sensor activity with good selectivity for CN− detection, considerable fluorescence amplification in the presence of CN− ion, and the desirable “Off–on” fluorescent responses toward CN− in the semi‐aqueous medium. The photophysical studies confirmed the A‐D‐A type molecule has a detection limit 0.163 μM for CN− sensing, which is lower than the WHO′s cyanide in water permitted limit. The simple synthetic probes 1 and 2 will offer up new possibilities for industrial effluent CN− detection and bio‐imaging of CN− in a variety of cell lines. This will undoubtedly aid in the understanding of the basic mechanism of CN− poisoning in the bloodstream.
Synthetic polymer materials have been surged to the forefront of research in the fields of tissue engineering, drug delivery, and biomonitoring in recent years. Biodegradable synthetic polymers are increasingly needed as transient substrates for tissue regeneration and medicine delivery. In contrast to commonly used polymers including polyesters, polylactones, polyanhydrides, poly(propylene fumarates), polyorthoesters, and polyurethanes, biodegradable polyphosphazenes (PPZs) hold great potential for the purposes indicated above. PPZ's versatility in the synthetic process has enabled the production of a variety of polymers with various physico-chemical, and biological properties have been produced, making them appropriate for biomedical applications. Biocompatible PPZs are often used as scaffolds in the regeneration of skeleton, bones, and other tissues. PPZs have also received special attention as potential drug vehicles of high-value biopharmaceuticals such as anticancer drugs. Additionally, by incorporating fluorophores into the PPZ backbone to produce photoluminescent biodegradable PPZs, the utility of polyphosphazenes is further expanded as they are used in tracking the regeneration of the target tissue as well as the fate of PPZ based scaffolds or drug delivery vehicles. This review provides a summary of the evolution of PPZ applications in the fields of tissue engineering, drug delivery, and bioimaging in recent 5 years.
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