A new metal complex, [Cu(NO3)2(C6H6N2O2)2(H2O)2], was synthesized from water–ethanol solutions of Cu(NO3)2 and 4-nitroaniline (PNA). The complex molecules are located on inversion centers in monoclinic crystals with space group P21/c. The copper(II) ions are monodentately coordinated by two neutral PNA molecules through the nitrogen atom of the amino group, two NO3
− anions and two water molecules. The coordination polyhedron of the central ion is a distorted octahedron as a result of the Jahn–Teller effect. There is a weak intramolecular hydrogen bond between the N—H group and the oxygen atom of one nitrate anion. Six relatively weak intermolecular hydrogen bonds associate the complex molecules into a three-dimensional network. The Hirshfeld surface analysis indicates that 55.8% of the intermolecular interactions are from O...H/H...O contacts, 13.3% are from H...H contacts while other contributions are from C...O/O...C, C...H/H...C, O...O and other contacts.
Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. During the recent years, there has been intense investigation of different classes of thiadiazole compounds, many of which possess extensive biological activities. We will discuss a novel extracted isomers of 1,3,4-thiadiazoles derivatives and their possibilities for pharmaceutical and industrial importance. The process of extraction brought to the formation isomers that differ chemically and on crystallographic parameters. The new derivatives of 1,3,4-thiadiazole, isomers with brutto-formula C13H14N2O2S3, crystallize in the triclinic and monoclinic systems, space groups P-1 and P21/c, respectively. Inter-and intramolecular hydrogen bonds help to stabilize the structures. Both hydrogen bonds networks can be described using graph set theory. They will be discussed in detail. The present review highlights the recently synthesized derivatives of 1,3,4-thiadiazole possessing important biological activities.This project is funding in the framework of grant A9-T-050-Uzbekistan on the synthese and study of the antitumant activity of new compounds.
B a k h r o m B a B a e v Embassy of the Republic of Uzbekistan Civil society institutions crucial in securing human rights and freedoms A roundtable discussion has taken place in Paris to deliberate on the experience of Uzbekistan and France in civil society development
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