Few
xanthene-based near-infrared (NIR) photoacoustic (PA) dyes
with absorbance >800 nm exist. As accessibility to these dyes requires
long and tedious synthetic steps, we designed a NIR dye (XanthCR-880) with thienylpiperidine donors and a xanthene acceptor that is accessible
in 3–4 synthetic steps. The dye boasts a strong PA signal at
880 nm with good biological compatibility and photostability, yields
multiplexed imaging with an aza-BODIPY reference dye, and is detected
at a depth of 4 cm.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.