Background: The role and mechanism of NAADP, an endogenous Ca2+ mobilizing nucleotide, in autophagic regulation remain to be determined.Results: Activation of NAADP/TPC2 signaling induced the accumulation of autophagosomes.Conclusion: The NAADP/TPC2 signaling inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.Significance: Development of agonists or antagonists of NAADP should provide a novel approach to specifically manipulate autophagy.
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