Our results suggest that seizure generation and spread during spontaneous mesial-temporal LVF onset events in humans may result from increased inhibitory neuron firing that spawns a subsequent increase in excitatory neuron firing and seizure evolution. Ann Neurol 2018;84:588-600.

This machine learning approach, based on features extracted from the PLV, effectively identified electrodes within the SOZ. The approach has the potential to assist clinicians in surgical decision-making when pre-surgical intracranial recordings are utilized.

Ripples and spikes generated in the left temporal neocortex are associated with impaired verbal episodic memory encoding. Although physiological and pathological ripple oscillations were not distinguished during cognitive tasks, our results show an association of undifferentiated ripples with impaired encoding. The effect was sometimes specific to regions outside the SOZ, suggesting that widespread effects of epilepsy outside the SOZ may contribute to cognitive impairment.

In this paper, we present a novel and precise way of estimating the direction and delay of arrivals in multipath environment for channel estimation purposes. Recently, super-resolution methods have been widely used for highresolution direction of arrival (DOA) or time difference of arrival (TDOA) estimation. The proposed algorithm, called JDTDOA, is applicable to space-time channel estimation for space-time processing systems that employ hybrid DOA/TDOA technology. The estimator is based on conventional MUSIC algorithm to find the DOA and uses a standard correlator along with spline interpolation to find the TDOA of each arrival. In the interest of estimating the channel's characteristics, each direction must be associated with its proper delay of arrival. To achieve this, we suggest a very simple and optimum beamforming by performing maximum variance distortionless response applied to each DOA found. The output at each DOA beamforming process gives the recovered signal from the relevant direction. A correlation is then made between each recovered signals which can be interpolated by cubic spline. The peak in correlation figure indicates the specific delay between the signal arrivals coming from the two considered direction.

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