A facile method for the synthesis of various propargylamines derivatives with different structural parts has been reported. The reaction has consisted of onepot coupling between aldehydes, secondary amines and terminal alkynes using CuCl as a catalyst and choline chloride/urea DES as a cheap and biocompatible reaction media. The procedure is free of using toxic solvents and used CuCl as an available, inexpensive and non-toxic catalyst. Using this methodology, 15 different propargylamine derivatives were successfully synthesized at 60 C in 15 hr, mostly in good yields.

A safe and straightforward method has been developed for the synthesis of various naphthofurans derivatives from readily available α,β‐unsaturated nitroalkenes and naphthols in ChCl/ZnCl2 DES media via a cascade reaction. The employed methodology is solvent‐free, and ChCl/ZnCl2 DES is applied with the reaction media and catalyst dual roles. Via this reaction, 13 different naphthofuran derivatives, starting from both α‐ ad β‐naphthols have been prepared at 60 °C in 4 h with 86–94 % yields.

An environmentally friendly method is presented here for the synthesis of various benzofuran derivatives using CuI catalyst. In this line, a one‐pot, 3‐component reaction of alkynes, different aldehydes, and amines is employed in choline chloride‐ethylene glycol deep eutectic solvent as an available, cheap, and green media. The employed method includes easy workup and good yields. In this work, 12 different benzofuran derivatives have been prepared in 7 h at 80°C.

Several benzazoles (benzoxazoles, benzothiazoles, and benzimidazoles) and azoles (1H-1,2,4-triazole-5(4H)-thiones and 1,2,4-oxadiazoles) bearing a sulfonamide moiety were efficiently prepared via the reactions of dimethyl (arylsulfonyl) dithioimidocarbonate derivatives and their 2-aminobenzene precursors, thiosemicarbazides, and amidoximes, respectively, in the presence of K(2)CO(3) as a base in aqueous ethanol (25%) as a green media in moderate to excellent yields.