Objective:To investigate the hepatoprotective activity of the aqueous extract of the aerial parts of Portulaca oleracea (P. oleracea) in combination with lycopene against carbon tetrachloride induced hepatotoxicity in rats.Materials and Methods:Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of carbon tetrachloride (0.1 ml/kg b.w for 14 days). The aqueous extract of P. oleracea in combination with lycopene (50 mg/kg b.w) was administered to the experimental animals at two selected doses for 14 days. The hepatoprotective activity of the combination was evaluated by the liver function marker enzymes in the serum [aspartate transaminases (AST), alanine transaminases (ALT), alkaline phosphatase (Alk.P), total bilirubin (TB), total protein (TP) and total cholesterol (TC)], pentobarbitone induced sleeping time (PST) and histopathological studies of liver.Results:Both the treatment groups showed hepatoprotective effect against carbon tetrachloride induced hepatotoxicity by significantly restoring the levels of serum enzymes to normal which was comparable to that of silymarin group. Besides, the results obtained from PST and histopathological results also support the study.Conclusions:The oral administration of P. oleracea in combination with lycopene significantly ameliorates CCl4 hepatotoxicity in rats.
Aim:The aqueous extract of leaves of Murraya koenigii was studied for its renoprotective potential against unilateral renal ischemia reperfusion (RIR) injury in male Wistar rats.Materials and Methods:Healthy adult male Wistar rats were divided into five groups (n = 8) and were treated with 200 mg/kg., p.o. of aqueous extract of M. koenigii (AEMK) for 30 days to assess both preventive and curative effects of AEMK. Except Group I, RIR was induced to all the groups by clamping the left renal artery using artery clamp for 1 h followed by reperfusion by removing the clamp. Groups II and III underwent RIR at 30th day whereas RIR was induced in Groups IV and V at 1st day of treatment schedule. Biochemical parameters (serum creatinine, blood urea nitrogen, serum total protein and serum Na+), urinary parameters (urine output, urinary creatinine, urinary urea, urinary total protein, urinary Na+), in vivo anti-oxidants, renal myeloperoxidase (MPO) activity and histopathology of kidneys were monitored. Statistical significance was set at P < 0.05.Results:Rats were treated with AEMK significantly (P < 0.05) restored the serum and urinary parameters with significant (P < 0.05) improvement in endogenous anti-oxidants such as superoxide dismutase, catalase and reduced glutathione and decreased levels of malondialdehyde and renal MPO when compared with the control groups. Histopathological examination also supported the biochemical and urinary tests.Conclusions:Aqueous extract of M. koenigii possesses both preventive and curative effects against RIR injury.
Objective: The aim of this study was to screen the hepatoprotective effect of ethanolic extract of Curcuma longa on antitubercular drugs induced hepatotoxicity in rats. Methods: Hepatotoxicity was induced by a combination of three antitubercular drugs [isoniazid (I) 7.5mg/kg, Rifampin (R) 10 mg/kg and Pyrazinamide (P) 35mg/kg] given orally as a suspension for 30 days in rats. 95% ethanolic extract of Curcuma longa (500mg/kg) was given orally for 30 days. The hepatoprotective activity was assessed using various biochemical parameters like SGOT, SGPT, ALP, Total bilirubin, unconjugated bilirubin, and total protein. At the end of study histological examinations were also carried out. Results: Treatment with Curcuma longa significantly (P<0.05-P<0.001) prevented the drug-induced an increase in serum levels of hepatic enzymes. Histopathology of liver tissue showed that Curcuma longa preserved the normal hepatic cell architecture. Conclusion: The results of this study indicate the protective effect of Curcuma longa against liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional uses.
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