The essential oil of the leaves of Eugenia uniflora L. (Myrtaceae) was investigated by GLC, NMR, and mass spectrometry. Main constituents are furanodiene (27a), and the hitherto unknown selina-1,3,7(1 1)-trien-8-one (36) and oxidoselina-1 ,3,7(1 1)-trien-8-one (41). The oil contains almost no monoterpenes, but several known sesquiterpenes. The characteristic odor of the oil is determined by the mushroom-like, woody, and spicy smelling furanodiene (27a), and by the green and cucumber note of selinatrienone (36).

Further examination of the active ethanolic extract of the root bark of Cleistopholis patens by using bioassay-directed fractionation resulted in the isolation of a new alkaloid, 3-methoxysampangine (compound I), together with three known alkaloids, eupolauridine (compound II), liriodenine (compound III), and eupolauridine N-oxide (compound IV). The proposed structure of compound I was based on its physicochemical properties and spectral data. 3-Methoxysampangine exhibited significant antifungal activity against Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans. This is the first report of the isolation of liriodenine (compound III) from the root bark of C. patens.

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