contents too basic and rather biased in favour of hypothermia. Those with interest in pre-clinical hypothermia research will be cognizant with the hoard of endpoints cited but may desire more detail and a wider reference base to that provided. Clinicians involved in clinical research will immediately sense its American' perspective and may be disappointed with the rather super®cial way`lessons for the future' are handled. Frankly, there are better reviews on the failings of clinical trial design and protocol implementation in the literature.This book may be of some interest to European intensivists and anaesthetists occasionally working in the ®elds of brain trauma, subarachnoid haemorrhage, ischaemic stroke, and resuscitation who wish to update themselves on current thinking on hypothermia and brain ischaemia. However, given the recent publication of excellent reviews on this subject I could not recommend European readers to purchase this book because of its hefty price.N. M. Dearden Leeds, UK
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