A series of Mannich bases have been synthesized by treating thiourea, isatin with formaldehyde and different aromatic primary and secondary amines. The structures of compounds were established based on IR, 1 H NMR and Mass spectral data. The title compounds were screened for antibacterial and antifungal activities. The compounds S 4 , S 6 and S 10 with 1-benztriazolyl, 1-diethylamino and 1-dimethylamino substituted derivatives exhibited significant antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Klebesiella pneumonia, whereas the compounds S 4 , S 9 and S 10 with 1-benztriazolyl, 1-piperazinyl and 1-dimethylamino substituted derivatives exhibited better antifungal activity against Aspergillus niger.
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