Of nine antihistamines screened for in vitro antibacterial activity, ambodryl (bromodiphenhydramine hydrochloride) and benadryl (diphenhydramine hydrochloride) were the most active. At 50 to 100 μ/ml concentrations these inhibited a large number of Gram negative and Gram positive bacteria in vitro, with ambodryl having a broader spectrum. In vivo tests showed that the compounds at single doses of 3 and 1.5 μg/g body weight protected mice against a challenge with a virulent strain (LD50) of Salmonella typhimurium, and also significantly reduced the multiplication of this organism in the liver, spleen and blood of the protected animals in comparison with the unprotected controls.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.