In the present scenario, researchers focused themselves on thiazolidine ring-based compound to cure Diabetes Mellitus. Diabetes mellitus is a heterogeneous group of disease, characterized by a state of chronic hyperglycemia, resulting from diversity of etiologies, environmental and genetic, acting jointly. The thiazolidinediones used in oral combination therapy in management of patients with type II diabetes who have insufficient glycemic control despite maximal tolerated dose of oral mono-therapy with either metformin or sulphonyl urea.
Synthetic organic chemistry involves selection and optimization of lead, synthesis and characterization of work for practical purposes. A series of new thiazolidinedione derivatives have been designed and synthesized through microwave-assisted technique. The synthesized compounds were screened by Insilco methods like molecular docking, QSAR studies in order to explore the anti-diabetic activity, synthetic assessability of compounds against the peroxisome proliferator-activated the receptor (PPARγ). Compounds which showed higher glide score than standard (Pioglitazone) were synthesized using the microwave. Compounds were characterized with the help of FT-Infrared spectroscopy, Proton NMR, C-13 NMR spectroscopic studies and Lc-Ms.
Diabetes Mellitus is the most common disease that poses a challenge to human health due to its secondary complications and resistance. Therefore, an attempt was made to synthesize novel compounds from thiazolidinedione moiety to treat the disease effectively and target diabetic complications. The synthesized compounds were tested for their physical parameters and characterised using NMR and IR spectra. They were also evaluated for STZ induced anti-diabetic activity in albino rats. The Compounds P5, II A8 and A9 were found effective in comparison with a standard drug, Pioglitazone. The other compounds were also effective but a reduction in activity is seen might be due to the inefficient binding to the PPAR receptors.
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