No abstract

The current goal of the research work was to develop and evaluate Docetaxel nanoparticles as potential carrier system to facilitate targeted delivery to tumour cells. Central composite design was used to optimize Docetaxel loaded Pluronic F68 nanoparticles. Drug loaded Pluronic F68 nanoparticles were prepared by anti solvent precipitation method and was characterized for FTIR, DSC, Entrapment efficiency, Drug Content, % Yield, SEM and in vitro release studies. Docetaxel with Pluronic F68 showed no interaction based on the results from FTIR and DSC. Polymer concentration affected the entrapment efficiency, drug content and percentage yield. The more the polymer concentration the more was the yield, the more was the entrapment efficiency. The in-vitro release study was performed and at 12 th hour the release ranged between 81.28-91.71 %. The average particle size was found to be 62.51 nm.

The objective of the present research work was to design, develop and optimize Letrozole loaded polymeric nanoparticles in order to potentially maximize the therapeutic efficiency, to decrease toxicity as well as to minimize the drug side effects. Pectin and Tween 80 were used as polymer and surfactants respectively. Letrozole polymeric nanoparticles (LTZ-PNPs) were prepared by precipitation method. The drug-polymer compatibility was studied using Fourier Transform Infrared (FTIR) and Differential Scanning Microscopy (DSC). The formulations' optimization was done by design expert. The drug content (DC) and entrapment efficiency (EE) of nanoparticles (NPs) were evaluated by UV-Vis microscopy. The particle size of NPs were investigated using dynamic light scattering technique. The Franz diffusion cell was used for In-Vitro drug release studies. Accelerated stability studies were performed as per ICH guidelines. FTIR and DSC studies revealed compatibility between Letrozole and pectin. The DC was found to be uniform within all formulations (95%) and 96.87 % for the optimized formulation (F9). The E.E was found to be in the range of 68.87 to 95.11%. The NPs particle size was between 194 nm and 333 nm; F9 showed the particle size of 218.5 nm. Drug release from all formulated NPs followed nonfickian transport, thus the release mechanism was diffusion. The optimized formulation did not show a large variation in DC and EE when stored at 40 °C/75% RH as per ICH guidelines.