1. Adult rats were maintained on a protein-deficient diet for 6 weeks following which laparotomy was performed and peritoneal wounds of standard size were constructed,2. The diet resulted in a progressive weight loss and a fall in plasma protein. Tissue protein, expressed as percentage protein in dried voluntary muscle, did not fall significantly.3. Following laparotomy the rats were killed in groups on successive days and the peritoneal wounds were removed for measurement of area and for histological examination.4. There was no apparent difference between control and protein-deficient animals in the rate or extent of peritoneal wound contraction although there was histological evidence of delay of collagen formation in the protein-deficient animals. This supports the theory that collagen formation is not a function of wound contraction.
CORRESPONDENCEBRrrDIC= 713 that the incidence of 4% claimed by Dressler2 does not apply in this country and that the figure of 1 % suggested by Drs. Davidson, Oliver, and Robertson is probably nearer the truth for us.The relapsing course of acute non-specific pericarditis. its associated pleural and pulmonary involvement, and its favourable response to steroid therapy suggest that the same mechanism is at work in this disease, in the post-myocardial-infarction syndrome, the post-commissurotomy syndrome, and in the lafe complications of direct trauma of the heart3, and that this mechanism may well be an autoimmune reaction.-I am, etc., Newcastle upon Tyne 7.W. G. A. SWAN.
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