Plants known to possess several antimicrobial compounds are used in all traditional medicine. Our study was to screen the leaf extracts of Aloe vera, Datura stromonium, pongamia pinnata, Lantona camara , Calotropis procera. These plants were collected and aqueous and alcoholic extracts were prepared by decoction and hot percolation process. Microbes for study are staphylococcus, E.coli and Aspergillus species. They were isolated from different sources and identified by morphological and chemical tests. Different dilutions of the test drugs were prepared with saline and by using turbidity method MIC was found and anti fungal activity by spore germination method. Alcoholic extracts displayed higher antibacterial and anti fungal activity than aqueous extract. Results concluded that Aloevera had the highest and strong activity against S.aureus and E.coli. Lanata camara does not show anti bacterial and anti fungal activity. Pongamia pinnata aqueous extract showed better anti E.coli activity than its alcoholic extract. Datura stramonium showed better activity against staphylococcus aureus & showed little anti Aspergillus activity. Calotropis procera showed antibacterial activity against Staphyloccus aureus & E.coli and does not showed anti Aspergillus activity. © 2011 IGJPS. All rights reserved
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