Article HistoryAnnotation. The therapeutic and prophylactic efficacy of the "Lactobacterin-TK2" probiotic for correction of clinical and microbiological changes in diarrhea of calves under farming conditions has been studied. The therapeutic efficacy showed that the drug product results in complete recovery. Findings on the calves' productivity showed that animals in the experimental groups grew more intensively than animals in the control group during the drug product administration by calves. Use of "Lactobacterin-TK2" probiotic in the treatment and prevention of gastrointestinal infections in calves has provided 100% therapeutic and preventive efficacy. We believe that the effect has been obtained due to the sanitation of the animals intestines from pathogenic flora by suppressing of pathogenic and conditionally pathogenic bacteria reproduction with lactobacilli as a result of their antagonistic activity and colonization of the intestine freed ecological niche with normal microbial flora, stimulation of humoral and cellular immunity factors, level of nonspecific resistance of the organism, activation of metabolic processes, normalization of intestinal microbiocenosis in calves. All this immediately influenced the improvement of digestion processes, which led to more intensive growth and development of animals.
The aim of this study was to comparatively evaluate the efficacy of different antimicrobial agents against interdigital necrobacillosis (IN) in cattle to identify the treatment with the greatest benefit. A network meta-analysis was used to synthesise empirical results from randomised controlled trials. Four studies with five interventions for 565 animals were included. The meta-analysis found no significant differences between the risk ratios for the antimicrobials versus placebo. However, ceftiofur sodium administered intramuscularly at a dose of 1.0 µg/kg body weight every 24 h for 3 days showed a better clinical response than 6.6 µg of oxytetracycline, 2.5 µg of tulathromycin, the placebo and 0.1 µg of ceftiofur sodium. The results show the best efficacy for 6.6 µg of oxytetracycline and 1.0 µg of ceftiofur sodium. Nevertheless, the latter is likely to be superior to oxytetracycline in terms of its pharmacodynamic and pharmacokinetic properties. Thus, 1.0 µg of ceftiofur sodium appears to provide the best therapeutic activity against IN in cattle. Further well-designed studies are required.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.