Summary The influence of granulocyle-colony stimulating factor (G-CSF) on thymoc>te subsets and peripheral blood leucocytes in leukaemia LI2IO-bearing mice was evaluated. Leukaemia-bearing mice have a markedly reduced L3T4*Lyt2* thymocyte subpopulation. We observed 'correction' of relative values of thymocyte subpopulations induced by treatment of mice with a G-CSF preparation. The suggestion is presented that this could result from liberation of lymphocyte T precursor cells from the bone marrow and increased homing of them into the thymus. The direct or indirect influence of G-CSF on the L3T4*Lyt2* subpopulation of thymocytes is discussed.
SUMMARY. The concentration of plasma prekallikrein (PK) in five patients with hepatocellular carcinoma (HCC) has been measured and related to levels in 18 patients with liver cirrhosis (LC) and 30 healthy subjects. It was found that the mean PK level was significantly increased in patients with HCC, while patients with LC demonstrated lower concentrations, as compared with healthy subjects. The results indicate that PK might be useful in screening cirrhotic patients for HCC. Longitudinal studies of PK in a larger group of patients at risk of developing HCC are therefore recommended.
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