Poly(N-isopropylacrylamide-co-N,N′-dimethylaminoethyl methacrylate sulfate) [P(NIPAM-co-DMAEMASA)] was prepared from N-isopropylacrylamide (NIPAM) and N,N-dimethylaminoethyl methacrylate sulfate (DMAEMASA) monomers, and its properties were compared with those of poly(N-isopropylacrylamide-co-N,N′-dimethylaminoethyl methacrylate) [P(NIPAM-co-DMAEMA)]. The copolymers were characterized by swelling measurements in distilled water (10-40 °C) and buffer solutions (I ) 0.1 M, pH ) 2.2-10.0), FTIR, DSC, and SEM methods. The ESV's of the NIPAM-DMAEMASA copolymers in distilled water were 5 times higher than those of P(NIPAM-co-DMAEMA); they decreased with an increase in comonomer (DMAEMASA/DMAEMA) content for both copolymers. While NIPAM-DMAEMASA copolymers did not display any phase transition with temperature, the LCST of the NIPAM-DMAEMA copolymer was determined as 20 °C. Both copolymers displayed a phase transition at pH ) 5.0, but the pH of the phase transition for NIPAM-DMAEMA gels shifted to 7.0 with increased DMAEMA content. Glass transition temperatures of NIPAM copolymers did not change with the type and content of comonomer.
Lipoid proteinosis (LP), also known as Urbach‐Wiethe disease is a rare, autosomal recessive disorder associated with deposition of acid‐Schiff (PAS)‐positive hyaline‐like material in various tissues including skin, mucosal membranes and internal organs. The aetiology of LP is currently unknown. A 17‐year‐old male complaining of oral lesions and tooth pain was referred to our clinic, depending on characteristic infandible hoarseness, pox‐like and acneiform scar‐like lesions on his face, beaded eyelid papules, loss of hair, tuberous nodules on the elbows and generalized skin thickening had been diagnosed with LP. He had the characteristic old‐looking appearance. Intraoral examination showed macroglossia with a thickened frenulum and lateral impressions of teeth, yellowish papules on the tongue and yellowish deposits on the soft palate. There wasn't any structural abnormalities in radiographic examination. He had no other systemic disorder. He had poor oral hygiene, severe periodontal problems and multiple severe caries lesions. The patient was evaluated for the individual treatment needs of the problems he had been. The teeth extractions, restorative and periodontal treatments were done. Intraoral tissues were fragile, and healing process was observed to be slower than usual. In this case, limited mouth opening, macroglossia and the thickened oral mucosa restricted the treatment procedures in oral region. Throughout medical treatment patient's oral health status will be followed. This report pointed out to the rare finding of gingival hyperplasia due to hyalin‐like material deposition in gingival tissues, which was not induced by any drug therapy.
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