Our study is the first to use normative ICA in a clinical sample and indicates its potential utility as a diagnostic tool. The findings provide consistent results based on EEG source localization in OCD and are of practical interest for therapeutic interventions.
Theta burst stimulation (TBS) is a modified form of high-frequency repetitive transcranial magnetic stimulation (rTMS) with promising effect in chronic pain. The aim of our double-blind, sham-controlled, parallel-group, randomized study was to assess an efficacy of intermittent TBS (iTBS) in the treatment of patients with chronic orofacial pain. Nineteen patients (twelve females) with chronic orofacial pain were prospectively included and randomly assigned to single session of an active (iTBS) or sham (intermediate TBS; imTBS) stimulation delivered to the primary motor cortex (M1) contralateral to painful side. The primary outcome was pain relief assessed using a visual analogue scale (VAS) after stimulation and at the end of two-week follow- up. The secondary outcomes were changes in the quantitative sensory testing (QST). QST set the threshold for thermal and tactile (touch) sensation in the affected facial area. Intermittent TBS, compared with the sham, showed significant improvement in VAS after stimulation, but not at the end of two-week follow-up. Regarding the secondary outcomes (QST), we failed to find any significant difference between iTBS and sham. Our findings demonstrate that iTBS of M1 transiently provides transient and modest subjective pain relief in chronic orofacial pain.
We conclude that schizencephaly in our patient was at first asymptomatic and later developed into clinically manifest schizophrenia-like disorder. Both magnetic resonance imaging and EEG were essential tools for establishing this diagnosis.
ObjectiveRapid and robust antidepressant-like effect of ketamine in subanesthetic doses was already manifested in depressive patients. Maximum of mood improvement was shown within the period from 2 hours to 3 days. Previous studies proved predictive value of prefrontal QEEG theta cordance reduction after 1 week on a new antidepressant.Congruently with previous findings we hypothesised in our compressed model decrease of QEEG cordance in 10 minutes of ketamine hydrochloride infusion as the prediction of antidepressant response.Methods14 MDD patients (6F/8M) diagnosed with a moderate to severe depressive episode without psychotic symptoms were included. All of the participants received the 30 minutes lasting only infusion with subanesthetic dose of ketamine hydrochloride solution (0.54 mg/kg). EEG measurements on the baseline, after 10 and 30 minutes of infusion were taken into account in computation of QEEG cordance.Results9 (64.3%) of subjects responded to single ketamine infusion following day and 8 (88.9%) of them decreased QEEG cordance. T-test pair comparison found significant difference between baseline and after 10 minutes of ketamine infusion in responders (F = 4.12; p < 0.003).
ConclusionsPreliminary results have shown the tendency of prefrontal QEEG cordance to decrease as a ketamine response prediction. Larger sample size is needed to increased precision in estimates of cordance sensitivity and specificity. Combination of latest QEEG method and fastest-acting antidepressant-like effect of ketamine in this trail is unexampled. Supported by IGA (MH CR) No.NS10379-3, 1M0517 (MEYS CR), MZ0PCP2005 (MH CR). Local Ethics Committee approval has been granted.
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