Paget's disease of bone is a common condition in Britain,' which often causes bone pain and has a number of serious complications, including deafness and spinal cord compression. Limited success has been obtained with calcitonin injections against bone pain and in partially correcting some of the other complications. However, the response has not been complete, and relapse occurs whenever the drug is stopped.2 Calcitonin has to be given by injection, and side effects are common. The drug ethane-1-hydroxy-1,1-diphosphonate (EHDP, etidronic acid, Didronel) has recently become available in this country, bringing with it the promise of improved pain relief for patients with Paget's disease.EHDP is one of a number of diphosphonate compounds which are similar in structure to inorganic pyrophosphate. They inhibit the transformation of amorphous calcium phosphate into hydroxyapatite crystals, thus preventing mineralisation,3 but more importantly they inhibit bone resorption.4This action on bone resorption is the basis of the beneficial effect of EHDP in Paget's disease.
Intestinal anastomoses were performed on seventeen mongrel dogs by non‐suture invagination technique and by the conventional method. A comparative evaluation revealed the non‐suture technique to be easier and less time‐consuming. Also the tissue reaction was minimal. Encouraging results suggest further investigation prior to clinical trial of this relatively new technique.
Résumé. Des anastomoses intestinales sur dix‐sept chiens métis par l'invagination technique pas de suture et la méthode de convention. Une évaluation comparative a révélé que la technique pas de suture était plus facile et moins de temps était perdu. Aussi la réaction du tissu était minimum. Les résultats encourageants proposent un surcro***ît d'investigation antérieurement a l'expérience clinique de cette technique relativement plus nouvelle.
Zusammenfassung. Die Darmanastomosen von siebzehn Mischhunden durch die Intussuscep‐tiontecknik keiner Naht und die verabredete Methode. Eine vergleichende Abschatzung zeigte, daß die Tecknik keiner Naht leichter ist, und wenigere Zeitverschwendung hat. Auch war die Reaktion des Gewebes minderst. Die ermutigenden Ergebnisse suggerieren eine Forderung der Erforschung vor klinischem Versuch dieser Tecknik, die verhältnismäßig neuere ist.
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