Introduction and objectives: Burnout syndrome (BOS) is seen amongst Medical students which leads to chronic stress and need coping mechanisms to overcome it. This study aims to determine the prevalence of BOS, associated factors and coping strategies adopted by students of the Faculty of Medicine, Jaffna. Methodology: This descriptive cross sectional institutional based study was carried out among first to fourth year medical students. Data were collected using a self-administered questionnaire. BOS was measured using the Oldenburg Burnout Inventory (Student version)1. Data was entered and analysed using SPSS version 26. Chi Squared was used to assess the associated factors. Ethical clearance was obtained from the Faculty of Medicine, Jaffna. Results: A total of 561 were considered and the response rate was 81%(455). Male Female ratio was 1:1.5. BOS was seen in 381(83.7%), 86.3% were females, 88.5% were Sinhalese and 88.8% lived in hostels. A total of 104(86.0%) had English difficulties, 85%(239) felt homesick, 84.3% spent <2hours in leisure activities and 86.6% missed main meals. BOS was significantly associated with year of study(p=0.048), performance at examination(p=0.019), Use of social media(p=0.021), dietary habits(p=0.027) and interaction with teachers(p=0.032). The coping strategies were being positive(88.1%), getting advice(75.6%), listening to music(77%), finding comfort in religious activities(77.4%) and getting emotional support(77.9%). Keeping feelings to one's self and solving problems alone(54.5%) were commonly reported avoidant strategies. Conclusion: BOS among medical students is seen and some groups are more vulnerable. Year of study, performance at examination, dietary habits, use of social media and interaction with teachers contributed to the BOS.