Although giant congenital melanocytic nevus is a rare lesion, it causes significant deformity and carries a risk of malignant degeneration. Different surgical techniques for the lesion removal are described, including serial resection, resection with skin grafting, and resection and coverage with expanded skin flap (skin expanders). The aim of this study is to report the author's 40 years of experience with cases requiring at least 4 serial excisions to complete the treatment. Serial resection is an effective, safe, and simple technique that requires a lot of patience. Treatment often results in a single linear scar, requires no donor sites, nor large flaps. It is not subject to potencial complications of expanders and avoid aesthetic deformities depending on the location.

Nevus lipomatosus superficialis is a rare disorder characterized by a nevoid fatty growth within the papillary and reticular dermis. Lesions more often occur in the sacral, abdominal, or pelvic regions. A 36-year-old Brazilian female with giant nevus lipomatosus is reported. Our case seems to be the biggest reported in the literature.

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The subcutaneous fistulectomy is a surgical option in bridging hidradenitis suppurativa.

Injection of adipose tissue into corporal depressions to improve contour is not a new procedure. According to the literature, the grafted fat undergoes ischemia, producing a local inflammatory process and reabsorption of part of the injected volume, and the desired result is not achieved. Starting from the premise that vascular insufficiency occurs in the core of grafted tissue, leading to reabsorption, the authors of this paper studied the outcome of injection of small volumes of fat into facial depressions. The subjects, 16 patients with facial depressions (12 with Romberg's syndrome and 4 with lupus), were subjected to small volumes of adipose tissue grafting. Three to seven sessions of fat grafting were necessary to obtain a uniform facial contour. The interval between each procedure was 2–3 months. Ultrasonography and biopsies were performed. The cutaneous ultrasound demonstrated viable adipose tissue, confirming the pathological result.

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