A case of systemic mastocytosis with skin characteristics of telangiectasia macularis eruptiva perstans is reported. Systemic involvement was confirmed as a combination of highly increased urinary excretion of methyl imidazole acetic acid (Melm AA) and increased amounts of mast cells in skin, liver and colon transversum. Treatment with cimetidine (H2 receptor antagonist) resulted in diarrhea, however, the addition of cyproheptadine (H1 receptor antagonist) was beneficial in amelioration of the cutaneous symptoms of mastocytosis. The excretion of Melm AA was unchanged during treatment. After 7 months of continuous cimetidine and cyproheptadine treatment no side effects were observed.
baseline warts (imiquimod 11% vs. vehicle 6%; p = 0.488), Douglas JM Jr. Treatment of genital warts with an immunemore imiquimod-treated patients experienced a 50% reducresponse modi er (imiquimod). J Am Acad Dermatol 1998; 32: tion in baseline wart area (38% vs. 14%; p = 0.013). Use of 230-239. imiquimod was not associated with any changes in laboratory 3. Beutner KR, Tyring SK, Trofatter KF, Douglas JM, Spruance S, values, including CD4 count. It was not associated with any Owens ML, et al. Imiquimod, a patient-applied immune-response adverse drug-related events, and no exacerbation of HIV/AIDS modi er for treatment of external genital warts. Antimicrob Agents was attributed to the use of imiquimod. However, it appeared
Multiple sensitivity to metals is often seen in humans. This may be due to cross-reactivity or to multiple sensitization. The pattern of cross-reactivity to some metal compounds was studied, using the guinea pig maximization test method. Animals were induced with K2Cr2O7 and CoCl2, respectively, and then challenged with K2Cr2O7, CoCl2, NiSO4, PdCl2 and RhCl3. No simultaneous reactivity was recorded. This supports the view that simultaneous reactivity in patients to nickel-cobalt and to chromate-cobalt is due to multiple exposure and sensitization, and not to cross-reactivity. The purity of the test compounds was analysed.
A 10-year-old boy with T. violaceum tinea capitis was given systemic ketoconazole therapy. After 4 weeks' treatment, liver enzymes had increased considerably. Ketoconazole treatment was stopped and 3 weeks later the values had returned to normal. Three weeks thereafter the patient was completely cured and no relapses have occurred.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.