control mechanism which may automatically prevent excessive FSH stimulation of the ovaries. It should also be possible to produce synthetic LH-RH fairly cheaply. Nevertheless, many more clinical studies must be performed before we can define the proper place for LH-RH in the treatment of anovulatory infertility. Our studies in patients with anorexia nervosa prove that LH-RH can be used alone or in combination with HCG to induce follicular growth and maturation, ovulation, and pregnancy in such amenorrhoeic women, who have no evidence of endogenous ovarian activity. It remains to be seen if LH-RH is equally effective in other women with amenorrhoea.

Background: The aim of this study was to identify characteristics with independent predictive value for bowel cancer for use in the clinical assessment of patients attending colorectal outpatient clinics.Methods: This was a 22-year (1986-2007) retrospective cohort analysis of data collected prospectively from patients who attended colorectal surgical outpatient clinics in Portsmouth. The data set was split randomly into two groups of patients to generate and validate a predictive model. Multivariable logistic regression was used to create and validate a system to predict outcome. Receiver operating characteristic (ROC) curves and Hosmer-Lemeshow test were used to evaluate the model's predictive capability. The likelihood of bowel cancer was expressed as the odds ratio (OR). Conclusion:A clinical assessment that systematically identifies or excludes four symptom-age combinations, a mass and IDA (SAMI) stratifies patients as having a low and higher risk of having bowel cancer. This could improve patient selection for referral and investigation.

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