This is a report of a 32-year-old woman who presented with a hidradenoma papilliferum of the external auditory canal. The lesion bears a marked histologic resemblance to vulvar hidradenoma papilliferum and to intraductal papillioma of the breast and, as in the latter neoplasm it may malignancy. However, these are benign tumours and warrant only local resection. Clinical symptoms related to obstructure of the external ear and some hearing loss.This report emphasizes again the variety of neoplasms which occur under the generic name of ceruminoma. It is recommended that each of these tumours be classified according to its characteristic histologic features and that the term ceruminoma, as used at present, be abandoned.Adenomas of the ceruminous glands located in the external auditory canal are rare tumours (Batsakis et al., 1967; Cankar and Crowley, 1964; Pluec, 1977). About forty cases have so far been reported in the literature (Dehner and Chen, 1980). The histological classification of these benign ceruminous tumours is similar to that used for sweat gland tumours in other locations (Neldner, 1968; Pahor and O'Hara, 1975; Wetli et al., 1978).The most common type demonstrates features of glandular or tubular adenoma with epithelial structures which are similar to those of normal apocrine glands (Althaus and Ross, 1970; Anagnostou et al., 1974; Leitner, 1952; Camkar and Crowley, 1964). The second type of benign ceruminoma is the pleomorphic adenoma (Mark and Rothberg, 1951; Smith and Duarte, 1962; Pahor and O'Hara, 1975). Its histogenesis from ceruminous or ectopic salivary glands is still debated.The purpose of this paper is to report still another type of benign ceruminoma, namely the hidradenoma papilliferum which so far has only been mentioned as a theoretical possibility (Dehner and Chen, 1980).

No abstract

Abstract. Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. DNA measurement in one case showed an aneuploid tumor with a tetraploid DNA peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome.

To evaluate the pathology of lymphoid organs in low-birth-weight (LBW) human fetuses obtained after premature birth, morphological and morphometric features were studied. The ages of fetuses ranged from 22 to 32 weeks and their weights from 400 to 1180 g. In fetuses at 22-23 weeks without antigenic effects, the lymphoid organs were seen to be well developed and their differentiation was similar to that of full-term fetuses. In older unaffected fetuses (up to 32 weeks), a significant increase in size of the lymphoid organs and a rise in the rate of the differentiation of lymphoid cells were observed. Fetuses exposed to antigen-related diseases underwent morphological changes in lymphoid organs presumably as a consequence of the primary fetal immune reaction. These changes were characterized by a high increase in the number of lymphoblasts and partly of macrophages in the spleen and lymph nodes. Reactive centers in spleen follicles and in lymph nodes, and plasmocytes in all the lymphoid organs, were absent. The main reaction to severe antigenic influences was decompensation of the lymphoid organs manifested morphologically by their devastation as a result of a decrease in the number of small lymphocytes and, in severe cases, of lymphoblasts and macrophages. Exposure of fetuses to antigen-related diseases thus appears to cause marked changes in the normal ontogenesis of lymphoid organs.