Background: Many western studies have revealed that the vegetarian diet has a lesser risk of developing coronary heart disease (CHD). However, very few studies have been conducted in India on the association of diet with lipid profile and risk factors on developing CHD. The study aims to assess the association of risk factors with diet among CHD patients. Methods: The observational study was conducted for one year among CHD patients. Newly diagnosed CHD patients aged above 18 years and patients with or without comorbid conditions were included in the study. Patients with a past medical history of CHD and dyslipidemia were excluded. Patient's demographic details like age, gender, educational status, socioeconomic status, comorbidities, personal history like alcohol consumption, smoking, and diet were collected. The association of diet with total cholesterol (TC), low-density lipoproteins (LDL), high-density lipoproteins (HDL), and triglycerides (TG) were analysed. Results: Among 251 patients, 45 (18%) were found to be vegetarians, and 206 (82%) were omnivorous. Compared to vegetarians, omnivorous group has shown high levels of LDL (p-value 0.00), HDL (p-value 0.011) and TC (p-value 0.00). The omnivorous group has more likely to smoke and consume alcohol (p-value 0.013). Omnivorous group of CHD patients without lifestyle risk factors have shown high levels of LDL (p-value 0.000), TG (p-value 0.000) and TC (p-value 0.000). Conclusion: In the study, vegetarians found a beneficial association with coronary heart disease risk factors compared to omnivorous.
Background: Patient information leaflets (PILs) are effectively used to improve the patient's knowledge about medications, disease, diet, and lifestyle modifications. Aim: This study aims to develop and evaluate PILs for coronary heart disease patients. Materials and Methods: Primary, secondary, and tertiary resources were used to develop PILs. The developed PILs were validated by four doctors, four academic pharmacists, and one dietician. PILs design and layout was prepared using barker able leaflet design (BALD) criteria. PILs readability was assessed using the Flesch Reading Ease test (FRE), Flesch–Kincaid Grade Level (FKGL), and user readability methods. User opinion on PILs content and design was obtained from patients. Results: The FRE and FKGL readability scores were 61.5 and 7.4, respectively. The BALD criteria scores for English, Kannada, and Malayalam PILs were 28, 27, and 26, respectively. The overall user testing readability means scores had significantly improved from 45 to 79.30. Nearly 82.55% of patients rated the PILs as good design and content. Conclusion: The developed leaflet met the standard criteria for easy reading and comprehension. The majority of the patients gave good opinion on the content and design of the PILs.
Peripheral neurotoxicity is a major adverse effect of cisplatin chemotherapy. A prospective observational study was conducted among 200 cancer patients who received cisplatin between October 2017 and March 2018 to evaluate the occurrence, causality and severity of cisplatin induced peripheral neuropathy. A suitable data collection form was used to record patient information required for the study. Peripheral neuropathy was assessed using the National Cancer Institute- Common Terminology Criteria for Adverse Events (NCI-CTCAE). As per the results, 19 (9.5%) patients developed peripheral neuropathy after receiving cisplatin therapy. Peripheral neuropathy was reported higher in males (84.2%) compared to females (15.7%) and more within the age group of 58-65 years (38.6%). Most of the patients developed Grade I neuropathy (84.2%), followed by Grade II neuropathy (15.7%). The study concluded that the severity of peripheral neuropathy increases with higher cumulative doses of cisplatin.
Adverse Drug Reactions () are the problem that adds extra burden in the global scenario. Anticancer drugs can lead to severe negative consequences due to these . This study was conducted to assess the causality, severity and preventability of the identified of chemotherapeutic drugs among hospitalized patients diagnosed with cancer and also to analyze its management. A prospective observational study was conducted among cancer patients for a period of eight months. A total of 120 hospitalized patients who developed at least one ADR due to chemotherapy were included in this study. Data were collected and documented in a well-designed data collection form. A total of 166 were detected in 120 patients. 33(19.8%), was found as the most commonly identified ADR. Patients administered with as were found to be reported with the highest number of (36). According to Naranjo’s scale and WHO causality assessment, 110(66.2%) and 105(63.2%) were found probable. & scale of severity showed that 97(58.4%) were moderate and Modified and Thornton scale revealed that 129(77.7%) were not preventable. The patients prescribed with , , regimen should be strictly and continuously monitored for the symptoms of ADR. Early detection of ADR can decrease morbidity and mortality.
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