GRB 160625B, one of the brightest bursts in recent years, was simultaneously observed by Fermi and Swift satellites, and ground-based optical telescopes in three different events separated by long periods of time. In this paper the non-thermal multiwavelength observations of GRB 160625B are described and a transition phase from wind-type-like medium to interstellar medium between the early (event II) and the late (event III) afterglow is found. The multiwavelength observations of the early afterglow are consistent with the afterglow evolution starting at ∼ 150 s in a stellar wind medium whereas the observations of the late afterglow are consistent with the afterglow evolution in interstellar medium (ISM). The wind-to-ISM transition is calculated to be at ∼ 8×10 3 s when the jet has decelerated, at a distance of ∼ 1 pc from the progenitor. Using the standard external shock model, the synchrotron and synchrotron self-Compton emission from reverse shock is required to model the GeV γ-ray and optical observations in the early afterglow, and synchrotron radiation from the adiabatic forward shock to describe the X-ray and optical observations in the late afterglow. The derived values of the magnetization parameter, the slope of the fast decay of the optical flash and the inferred magnetic fields suggest that Poynting flux-dominated jet models with arbitrary magnetization could account for the spectral properties exhibited by GRB 160625B.