The effect of sodium hyaluronate eye drops in the treatment of severe keratoconjunctivitis sicca (KCS) was evaluated in a double masked crossover trial, comparing the effect of a 0.1% solution, a 0.2% solution and placebo in 20 patients. We found significantly decreased rose bengal staining and increased break-up time following 0.2% treatment compared to placebo. No significant difference was found in the Schirmer values and the cornea sensitivity. The patients significantly preferred sodium hyaluronate treatment. We conclude that sodium hyaluronate eye drops seem to be a valuable new agent in the management of KCS.
Forty-nine patients were included in a controlled clinical trial comparing the effect of topical non-steroid versus potent steroid preparation in acute anterior non-granulomatous uveitis. Twenty-five patients were randomized to 1% Indometacin and 24 patients to 0.1% Dexametason treatment 6 times a day. There was no difference between the two groups initially. After 7 days of treatment we found significantly less inflammation in the steroid treated group, this significant difference disappearing on day 14. We conclude that whenever adverse reactions to corticosteroid eye drops are suspected or proven, Indometacin eye drops make up a useful alternative to even strong solutions of steroids. The study was carried out in the following practices: L. Ahrendt, L. Damgård-Jensen, P. Eldrup-Jørgensen, J. Elmeros, H. Heuer, S. Jensen, M.H. Kjeldsen, P. Nellemann Sørensen, H. Petersen, N. Vedel-Jensen.
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