ABSTRACT. Atak-S laying hens are a high-performance hybrid obtained by crossing of the Rhode Island Red (RIR) X the Barred Plymouth Rock (BR) and are being produced in the Ankara Poultry Research Institute since 1997. Phenotypic and genetic improving studies are continuous for this hybrid. In this study three different SNPs, two from IGF1 and one from IGFBP2 genes, were examined in 150 Atak-S chickens. Genetic association of SNPs were compared to body weight and egg number till 32 weeks of age, body weight at sexual maturity, age at sexual maturity and also egg quality traits such as egg shell breaking strength, shell thickness, Haugh unit, albumen index, yolk index and shape index were statistically analyzed. Only IGF1(a) locus was in agreement with Hardy-Weinberg equilibrium, while, the rest of the loci were not. As a result of the comparisons performed to the three SNPs, it was determined that there was a significant association (P<0.05) between the T364C haplotypes of the IGF1(b) locus and body weight at 32 weeks of age, but there was not any association to the other traits.
BackgroundProcalcitonin is a polypeptide which is secreted as a response to bacterial stimulus and accepted as an early and sensitive marker of infection. In healthy subjects procalcitonin should be <0.1 ng/mL. In case of infection it may rises over 0.5 ng/mL[.1Its level in inflammatory diseases usually does not reach to such high levels as in infections. Differentiating infection and disease activation may be confusing in autoimmune diseases. For this purpose, there were several studies that evaluated the role of procalcitonin for excluding infection on suspicion of increased autoimmune disease activity.2 ObjectivesAs far as we know, there is no study in literature that evaluated procalcitonin levels in patients with primary Sjögren’s syndrome (pSS). Our aim is to evaluate procalcitonin levels in pSS and determine whether we can use it as a marker to differentiate infection from disease activation.MethodsThe following two groups of patients were included in the study: Forty-eight patients with pSS, who met ACR 2012 Classification Criteria for Sjögren’s Syndrome; and fifty-three subjects as control group who have no chronic diseases. Patients with possible infection were excluded according to their clinical evaluation and laboratory data. Then, serum procalcitonin levels were compared between the groups. Finally, we evaluated the correlation between disease activity, measured by Sjögren’s syndrome disease activity index (SSDAI) and procalcitonin levels.ResultsProcalcitonin levels in pSS group were found statistically higher than control group, whereas it was still in normal ranges (p<0,01). Furthermore, no correlation was found between disease activation and the procalcitonin levels (p=0.63).Abstract AB0605 – Table 1Demographic properties and Laboratory results of the subjectsSjögren(n=48)Control(n=53)p Gender(M/F)3/452/510,66Age53,50 (48,50–58,75)50,00 (43,50–55,00)0,04Sedimentation (mm)22,00 (12,00–31,75)18,00 (11,00–27,00)0,13CRP (mg/dl)3,27 (3,27–3,27)3,27 (3,16–3,27)0,16SSDAI score1,00 (1,00–2,00)N/AProcalcitonin(ng/ml)0,036 (0,031–0,044)0,020 (0,020–0,020)<0,01Haemoglobin (gr/dl)12,50 (11,65–13,50)12,80 (11,95–13,50)0,82Thrombocyte(103/uL)231,00 (189,50–278,00)265,00 (226,5–304,50)0,02WBC (/uL)6000,00 (5400,00–7200,00)6700,00 (5450,00–8000,00)0,15Creatinine (mg/dl)0,66 (0,59–0,76)0,57 (0,52–0,62)<0,01ALT (U/L)18,5 (13,25–25,00)18,00 (13,50–25,00)0,74AST(U/L)22,50 (19,00–25,00)21,00 (17,50–25,50)0,30Statistically significant P values were shown bold. Numerical variables were summarised by median [interquartile range]ConclusionsProcalcitonin levels were found higher in pSS patients. But, none of the patients had clinically significant increase in procalcitonin. We thought that with careful clinical evaluation, procalcitonin would be an indicator for differentiating infection from disease activation in pSS patients.References[1] Oczenski W, Fitzgerald RD, Schwarz S (1998) Procalcitonin: a new parameter for the diagnosis of bacterial infection in the peri-operative period. Eur J Anaesthesiol15: 202–9.[2] Korczow...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.